| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2022 |
| Язык | русский |
|
Абрамова Зинаида Ивановна, автор
|
| Библиографическое описание на языке оригинала |
Тихомирова М.В. Экспрессия поддерживающего белка NEDD9 как негативный прогностический маркер при немелкоклеточном раке легкого (НМРЛ) / М.В. Тихомирова, В.В. Бармин, Ю.А. Топчу, А.М. Мазитова, Е.Ю. Ратнер, А.А. Сабиров, З.И. Абрамова, А.Я. Денека // Сибирский онкологический журнал. – 2022. – Т. 21. – №4. – С.47–55 |
| Аннотация |
The purpose of the study was to assess the prognostic significance of a scaffolding NEDD9 protein in patients with non-small cell lung cancer (NSCLC). NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9) is a scaffolding protein in many intracellular protein cascades, such as PI3K-AKT-mTOR, Ras-ERK, which play key roles in tumor progression. several studies define the regulatory role of NEDD9 in progression of several solid cancers, including non-small cell lung cancer (NSCLC), however its role as a prediction biomarker is minimally assessed. Materials and methods. In the current study quantitative immunohistochemical (IHC) approach was utilized to characterize NEDD9 expression in a cohort of NSCLC primary tumor samples (n=16), and correlative statistical analysis was performed between NEDD9 expression and a set of patients' clinical and pathological characteristics. Results of the IHC analysis were validated using broader TCGA RNAseq dataset (n=566). Results. The study demonstrated significant difference between the expression of Nedd9 in stage iii tumors versus stages II and IV (p<0.05). Next, NEDD9 expression level was approximated to high and low (based on median h-score=56.14) and statistical survival analysis revealed a positive correlative trend between the decreased expression of NEDD9 and the decrease in the overall (OS) and progression-free survival (PFS) of the patients. Analysis of TCGA dataset harboring RNA seq data confirmed statistically significant correlation (p=0.05) between low NEDD9 expression and decreased OS. Conclusion. This study suggests that the expression of the scaffolding protein NEDD9, both at the protein and RNA levels, positively correlates with a negative prognosis in NSCLC, suggesting that it can potentially be used as a novel biomarker of disease progression. Further basic and clinical research defining the role of NEDD9 in the progression and metastasis of NSCLC are strongly warranted. |
| Ключевые слова |
немелкоклеточный рак легкого, общая выживаемость, беспрогрессивная выживаемость, поддерживающие белки, NEDD9, маркеры-предикторы |
| Название журнала |
СИБИРСКИЙ ОНКОЛОГИЧЕСКИЙ ЖУРНАЛ
|
| URL |
https://www.siboncoj.ru/jour/article/view/2242 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=271793 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абрамова Зинаида Ивановна |
ru_RU |
| dc.date.accessioned |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2022-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2022 |
ru_RU |
| dc.identifier.citation |
Тихомирова М.В. Экспрессия поддерживающего белка NEDD9 как негативный прогностический маркер при немелкоклеточном раке легкого (НМРЛ) / М.В. Тихомирова, В.В. Бармин, Ю.А. Топчу, А.М. Мазитова, Е.Ю. Ратнер, А.А. Сабиров, З.И. Абрамова, А.Я. Денека // Сибирский онкологический журнал. – 2022. – Т. 21. – №4. – С.47–55 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=271793 |
ru_RU |
| dc.description.abstract |
СИБИРСКИЙ ОНКОЛОГИЧЕСКИЙ ЖУРНАЛ |
ru_RU |
| dc.description.abstract |
The purpose of the study was to assess the prognostic significance of a scaffolding NEDD9 protein in patients with non-small cell lung cancer (NSCLC). NEDD9 (Neural precursor cell expressed, developmentally down-regulated 9) is a scaffolding protein in many intracellular protein cascades, such as PI3K-AKT-mTOR, Ras-ERK, which play key roles in tumor progression. several studies define the regulatory role of NEDD9 in progression of several solid cancers, including non-small cell lung cancer (NSCLC), however its role as a prediction biomarker is minimally assessed. Materials and methods. In the current study quantitative immunohistochemical (IHC) approach was utilized to characterize NEDD9 expression in a cohort of NSCLC primary tumor samples (n=16), and correlative statistical analysis was performed between NEDD9 expression and a set of patients' clinical and pathological characteristics. Results of the IHC analysis were validated using broader TCGA RNAseq dataset (n=566). Results. The study demonstrated significant difference between the expression of Nedd9 in stage iii tumors versus stages II and IV (p<0.05). Next, NEDD9 expression level was approximated to high and low (based on median h-score=56.14) and statistical survival analysis revealed a positive correlative trend between the decreased expression of NEDD9 and the decrease in the overall (OS) and progression-free survival (PFS) of the patients. Analysis of TCGA dataset harboring RNA seq data confirmed statistically significant correlation (p=0.05) between low NEDD9 expression and decreased OS. Conclusion. This study suggests that the expression of the scaffolding protein NEDD9, both at the protein and RNA levels, positively correlates with a negative prognosis in NSCLC, suggesting that it can potentially be used as a novel biomarker of disease progression. Further basic and clinical research defining the role of NEDD9 in the progression and metastasis of NSCLC are strongly warranted. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
немелкоклеточный рак легкого |
ru_RU |
| dc.subject |
общая выживаемость |
ru_RU |
| dc.subject |
беспрогрессивная выживаемость |
ru_RU |
| dc.subject |
поддерживающие белки |
ru_RU |
| dc.subject |
NEDD9 |
ru_RU |
| dc.subject |
маркеры-предикторы |
ru_RU |
| dc.title |
Экспрессия поддерживающего белка NEDD9 как негативный прогностический маркер при немелкоклеточном раке легкого (НМРЛ) |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
EN 
中文 
ES 
Карта сайта
