КФУ. Карточка публикации. A High Calcium Level-Based Model for Identifying Postsynaptic Effects of ATP

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A HIGH CALCIUM LEVEL-BASED MODEL FOR IDENTIFYING POSTSYNAPTIC EFFECTS OF ATP

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2022

Язык

английский

Авторы, сотрудники КФУ

Балтина Татьяна Валерьевна, автор

Гришин Сергей Николаевич, автор

Еремеев Антон Александрович, автор

Хайруллин Адель Евгеньевич, автор

Библиографическое описание на языке оригинала

Khairullin, A.E. A High Calcium Level-Based Model for Identifying Postsynaptic Effects of ATP/ A.E.Khairullin, S.N.Grishin, A.Y. Teplov, А.А. Еремеев, Т.В. Балтина, А.У. Зиганшин// BIOPHYSICS. - 2022. - Vol.67. - P.1007–1010

Аннотация

Identification of the pre- and postsynaptic effects of ATP is a methodological challenge. In our previous study, the role of P2 receptor signaling in synaptic transmission processes was evaluated using carbachol-induced skeletal muscle contractions. The search for models that can record the postsynaptic side of purinergic signaling during the application of electrical stimulation led to the idea of controlling the presynaptic terminal of ATP-mediated modulation. In in vitro experiments, electromyograms and mechanomyograms during isometric contractions of isolated nerve-muscle preparations of rat soleus and extensor digitorum longus (EDL) muscles revealed postsynaptic effects of ATP in the presence of a high intracellular calcium level. Thus, the effects of ATP in the presence of increased Ca2+ content were seen through contraction of soleus muscles that started to contract quicker by fifty percent and inhibition of contractility of EDL muscles; this was in accord with data obtained earlier on carbachol-induced contractions. We have demonstrated an ATP-dependent processes in the postsynaptic site that may contribute significantly to adaptation mechanisms in hypothermia.

Ключевые слова

Identifying Postsynaptic Effects, ATP, rat

Название журнала

Biophysics (Russian Federation)

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149919743&doi=10.1134%2fS0006350922050086&partnerID=40&md5=6d7ea919f9c83a5dcb7fa35795e1e94f

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https://repository.kpfu.ru/?p_id=278954

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Балтина Татьяна Валерьевна	ru_RU
dc.contributor.author	Гришин Сергей Николаевич	ru_RU
dc.contributor.author	Еремеев Антон Александрович	ru_RU
dc.contributor.author	Хайруллин Адель Евгеньевич	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Khairullin, A.E. A High Calcium Level-Based Model for Identifying Postsynaptic Effects of ATP/ A.E.Khairullin, S.N.Grishin, A.Y. Teplov, А.А. Еремеев, Т.В. Балтина, А.У. Зиганшин// BIOPHYSICS. - 2022. - Vol.67. - P.1007–1010	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=278954	ru_RU
dc.description.abstract	Biophysics (Russian Federation)	ru_RU
dc.description.abstract	Identification of the pre- and postsynaptic effects of ATP is a methodological challenge. In our previous study, the role of P2 receptor signaling in synaptic transmission processes was evaluated using carbachol-induced skeletal muscle contractions. The search for models that can record the postsynaptic side of purinergic signaling during the application of electrical stimulation led to the idea of controlling the presynaptic terminal of ATP-mediated modulation. In in vitro experiments, electromyograms and mechanomyograms during isometric contractions of isolated nerve-muscle preparations of rat soleus and extensor digitorum longus (EDL) muscles revealed postsynaptic effects of ATP in the presence of a high intracellular calcium level. Thus, the effects of ATP in the presence of increased Ca2+ content were seen through contraction of soleus muscles that started to contract quicker by fifty percent and inhibition of contractility of EDL muscles; this was in accord with data obtained earlier on carbachol-induced contractions. We have demonstrated an ATP-dependent processes in the postsynaptic site that may contribute significantly to adaptation mechanisms in hypothermia.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Identifying Postsynaptic Effects	ru_RU
dc.subject	ATP	ru_RU
dc.subject	rat	ru_RU
dc.title	A High Calcium Level-Based Model for Identifying Postsynaptic Effects of ATP	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU