| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2023 |
| Язык | английский |
|
Абрамова Зинаида Ивановна, автор
Ибрагимов Булат Рафисович, автор
Скибо Юлия Валерьевна, автор
|
| Библиографическое описание на языке оригинала |
Ibragimov B.R, Skibo Yu.V, Abramova Z.I., Autophagy and LC3-associated phagocytosis: similarities and differences [Аутофагия и LC3-ассоциированный фагоцитоз: сходства и различия (Обзор)/ Б.Р. Ибрагимов, Ю.В Скибо, З.И. Абрамова]//Medical Immunology (Russia). - 2023. - Vol.25, Is.2. - P.233-252. |
| Аннотация |
Abstract. Previously, autophagy was termed as a mechanism used by the cells with a lack of essential
nutrients supporting homeostasis. Over the decade of studies, autophagy proved to be a more complex,
ambiguous mechanism. Its activation depends on the nature of stimulus, type of immune cells and the final
result. Both canonical and non-canonical autophagy, being similar in molecular events, but showing their
own distinctive features, are key processes in protecting the body from penetration of intracellular pathogens,
maintaining the required level of nutrients in the cell, and removing damaged organelles and cells. Canonical
autophagy probably evolved as a homeostatic response to cellular stress and nutritional deficiencies, whereas
non-canonical autophagy emerged as a response to suppression of inflammation. Non-canonical autophagy,
hereinafter referred to as LC3-associated phagocytosis (LAP), combines the molecular mechanism of
phagocytosis with an autophagy mechanism characterized by ingestion of exogenous pathogens, formation of
phagosomes (laposomes) and enhanced fusion with lysosomes, followed by degradation of their contents.
Significant differences were found between the processes of LAP- and canonical autophagy, which are similar
in its mechanism of action. The presence of PI3K complexes in both processes, utilization and intracellular
degradation of the “cargo” which is not required for the cells and organism proceeding in the lysosomes, and
involvement of almost the same proteins provide similarity of their mechanisms. However, there are differences
in the initiation of the processes, e.g., different types of PI3K complexes (in autophagy, PI3K III class 1 and
2 types; in LAP PI3K III, class 3 type), usage of reactive oxygen species in LAP, different types of regulatory
proteins involved (ULK1, FIP200, ATG13 , Ambra1, WIPI2, ATG14 in autophagy; and Rubicon and NOX2
in LC3-associated phagocytosis), different number of layers in the membrane structure in which lysis occurs
(double-membrane autophagolysosome and single-layer membrane in laposomes) clearly depict the variety
of canonical and non-canonical autophagy. The two pathways are directed for different types of biological
objects, i.e., intracellular pathogens, dysfunctional proteins and organelles in autophagy, and extracellular
pathogens, apoptotic bodies, bacteria, utilized in LAP, thus making these mechanisms completely different in
their significance.
Collectively, the new data indicate that autophagy performed via both canonical and non-canonical
pathways, has evolved into a host defense mechanism capable of resisting immunological and pathogenic stress
and mediating immunological tolerance to both intra- and extracellular threats. The present review discusses
fundamental molecular differences between these mechanisms, as well as their role in immunity, based on the
latest literature data. |
| Ключевые слова |
аутофагия, LC3-ассоциированный фагоцитоз, LC3, Beclin-1, Vps34, аутоиммунитет, воспаление |
| Название журнала |
Medical Immunology (Russia)
|
| URL |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85158164418&doi=10.15789%2f10.15789%2f1563-0625-AAL-2569&partnerID=40&md5=286050752def88c161729cd93801eae3 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=282956 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Абрамова Зинаида Ивановна |
ru_RU |
| dc.contributor.author |
Ибрагимов Булат Рафисович |
ru_RU |
| dc.contributor.author |
Скибо Юлия Валерьевна |
ru_RU |
| dc.date.accessioned |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2023-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2023 |
ru_RU |
| dc.identifier.citation |
Ibragimov B.R, Skibo Yu.V, Abramova Z.I., Autophagy and LC3-associated phagocytosis: similarities and differences [Аутофагия и LC3-ассоциированный фагоцитоз: сходства и различия (Обзор)/ Б.Р. Ибрагимов, Ю.В Скибо, З.И. Абрамова]//Medical Immunology (Russia). - 2023. - Vol.25, Is.2. - P.233-252. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=282956 |
ru_RU |
| dc.description.abstract |
Medical Immunology (Russia) |
ru_RU |
| dc.description.abstract |
Abstract. Previously, autophagy was termed as a mechanism used by the cells with a lack of essential
nutrients supporting homeostasis. Over the decade of studies, autophagy proved to be a more complex,
ambiguous mechanism. Its activation depends on the nature of stimulus, type of immune cells and the final
result. Both canonical and non-canonical autophagy, being similar in molecular events, but showing their
own distinctive features, are key processes in protecting the body from penetration of intracellular pathogens,
maintaining the required level of nutrients in the cell, and removing damaged organelles and cells. Canonical
autophagy probably evolved as a homeostatic response to cellular stress and nutritional deficiencies, whereas
non-canonical autophagy emerged as a response to suppression of inflammation. Non-canonical autophagy,
hereinafter referred to as LC3-associated phagocytosis (LAP), combines the molecular mechanism of
phagocytosis with an autophagy mechanism characterized by ingestion of exogenous pathogens, formation of
phagosomes (laposomes) and enhanced fusion with lysosomes, followed by degradation of their contents.
Significant differences were found between the processes of LAP- and canonical autophagy, which are similar
in its mechanism of action. The presence of PI3K complexes in both processes, utilization and intracellular
degradation of the “cargo” which is not required for the cells and organism proceeding in the lysosomes, and
involvement of almost the same proteins provide similarity of their mechanisms. However, there are differences
in the initiation of the processes, e.g., different types of PI3K complexes (in autophagy, PI3K III class 1 and
2 types; in LAP PI3K III, class 3 type), usage of reactive oxygen species in LAP, different types of regulatory
proteins involved (ULK1, FIP200, ATG13 , Ambra1, WIPI2, ATG14 in autophagy; and Rubicon and NOX2
in LC3-associated phagocytosis), different number of layers in the membrane structure in which lysis occurs
(double-membrane autophagolysosome and single-layer membrane in laposomes) clearly depict the variety
of canonical and non-canonical autophagy. The two pathways are directed for different types of biological
objects, i.e., intracellular pathogens, dysfunctional proteins and organelles in autophagy, and extracellular
pathogens, apoptotic bodies, bacteria, utilized in LAP, thus making these mechanisms completely different in
their significance.
Collectively, the new data indicate that autophagy performed via both canonical and non-canonical
pathways, has evolved into a host defense mechanism capable of resisting immunological and pathogenic stress
and mediating immunological tolerance to both intra- and extracellular threats. The present review discusses
fundamental molecular differences between these mechanisms, as well as their role in immunity, based on the
latest literature data. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
аутофагия |
ru_RU |
| dc.subject |
LC3-ассоциированный фагоцитоз |
ru_RU |
| dc.subject |
LC3 |
ru_RU |
| dc.subject |
Beclin-1 |
ru_RU |
| dc.subject |
Vps34 |
ru_RU |
| dc.subject |
аутоиммунитет |
ru_RU |
| dc.subject |
воспаление |
ru_RU |
| dc.title |
Autophagy and LC3-associated phagocytosis: similarities and differences [Аутофагия и LC3-ассоциированный фагоцитоз: сходства и различия (Обзор)] |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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