КФУ. Карточка публикации. owards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines

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OWARDS ASYMMETRICAL METHYLENE BLUE ANALOGUES: SYNTHESIS AND REACTIVITY OF 3-N'-ARYLAMINOPHENOTHIAZINES

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2022

Язык

английский

Авторы, сотрудники КФУ

Падня Павел Леонидович, автор

Хадиева Алёна Игоревна, автор

Шибаева Ксения Сергеевна, автор

Другие авторы

Пискунов Александр , автор

Авторы, студенты КФУ

Раянов Мансур Рамилевич, автор

Библиографическое описание на языке оригинала

Khadieva A. Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines / A. Khadieva, M. Rayanov, K. Shibaeva, A. Piskunov, P. Padnya, I. Stoikov // Molecules. – 2022. – V. 27. – №. 9. – P. 3024.

Аннотация

The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 -arylamino)phenothiazines. This approach included the optimization of synthetic strategy by quantification analysis of the positive charge distribution in the cation of 3-N0 -arylaminophenothiazine derivative. The obtained experimental data are confirmed by DFT studies. Two synthetic routes for asymmetrical phenothiazine diary lamino derivatives were suggested and verified. The developed convenient and versatile synthetic approach makes it easy to obtain aromatic Methylene Blue isostructural analogues with various substituents. As a result, a series of novel 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 - arylamino)phenothiazines containing ester, tert-butoxycarbonyl, sulfonic acid, hydroxyl and amine groups were obtained in high yields.

Ключевые слова

Methylene Blue; phenothiazine; synthesis; reactivity; DFT

Название журнала

Molecules

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https://repository.kpfu.ru/?p_id=283526

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Падня Павел Леонидович	ru_RU
dc.contributor.author	Хадиева Алёна Игоревна	ru_RU
dc.contributor.author	Шибаева Ксения Сергеевна	ru_RU
dc.contributor.author	Пискунов Александр	ru_RU
dc.contributor.author	Раянов Мансур Рамилевич	ru_RU
dc.date.accessioned	2022-01-01T00:00:00Z	ru_RU
dc.date.available	2022-01-01T00:00:00Z	ru_RU
dc.date.issued	2022	ru_RU
dc.identifier.citation	Khadieva A. Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines / A. Khadieva, M. Rayanov, K. Shibaeva, A. Piskunov, P. Padnya, I. Stoikov // Molecules. – 2022. – V. 27. – №. 9. – P. 3024.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=283526	ru_RU
dc.description.abstract	Molecules	ru_RU
dc.description.abstract	The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 -arylamino)phenothiazines. This approach included the optimization of synthetic strategy by quantification analysis of the positive charge distribution in the cation of 3-N0 -arylaminophenothiazine derivative. The obtained experimental data are confirmed by DFT studies. Two synthetic routes for asymmetrical phenothiazine diary lamino derivatives were suggested and verified. The developed convenient and versatile synthetic approach makes it easy to obtain aromatic Methylene Blue isostructural analogues with various substituents. As a result, a series of novel 3-N0 -arylaminophenothiazines and asymmetrical 3,7-di(N0 - arylamino)phenothiazines containing ester, tert-butoxycarbonyl, sulfonic acid, hydroxyl and amine groups were obtained in high yields.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	owards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N'-Arylaminophenothiazines	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU