КФУ. Карточка публикации. Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility

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PACEMAKER CURRENTS ARE INVOLVED IN THE REGULATION OF 3-WEEKOLD RAT'S ATRIAL MYOCARDIAL CONTRACTILITY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2023

Язык

русский

Авторы, сотрудники КФУ

Зефиров Тимур Львович, автор

Зиятдинова Нафиса Ильгизовна, автор

Купцова Анна Михайловна, автор

Фасхутдинов Ленар Ильсурович, автор

Хисамиева Луиза Ирековна, автор

Авторы, аспиранты КФУ

Шакиров Ранис Ришатович, автор

Библиографическое описание на языке оригинала

Kuptsova A.M. Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility /A.M. Kuptsova, L.I. Khisamieva, L.I. Faskhutdinov, R.R. Shakirov,N.I. Ziyatdinova, T.L. Zefirov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1461-1462.

Аннотация

Hyperpolarization-activated cyclic nucleotide-regulated channels (HCN4) are key membrane proteins involved in the initiation and regulation of heartbeat. The pacemaker cells in the sinoatrial node generate the electrical impulse that underlies the contraction of atrial and ventricular cardiomyocytes. HCN4 channels contribute to the control of resting membrane potential and rhythmic activity of excitable cells expressing these channels. In addition to abundant expression in the pacing and conduction system, the membrane of adult rat working myocardium cells is characterized by low levels of HCN channels. However, in the early embryonic stages, HCN4 channels is abundantly transcribed throughout the heart and makes an important role in ventricular myocyte automatism triggered by If. By birth, HCN4 channels transcription is suppressed in working-type cardiomyocytes and remains at low levels in the adult body, which prevents pathological remodeling of the heart.

Ключевые слова

Pacemaker currents, 3-weekold rat?s, atrial myocardial contractility

Название журнала

Biophysical Journal

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https://repository.kpfu.ru/?p_id=290414

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зефиров Тимур Львович	ru_RU
dc.contributor.author	Зиятдинова Нафиса Ильгизовна	ru_RU
dc.contributor.author	Купцова Анна Михайловна	ru_RU
dc.contributor.author	Фасхутдинов Ленар Ильсурович	ru_RU
dc.contributor.author	Хисамиева Луиза Ирековна	ru_RU
dc.contributor.author	Шакиров Ранис Ришатович	ru_RU
dc.date.accessioned	2023-01-01T00:00:00Z	ru_RU
dc.date.available	2023-01-01T00:00:00Z	ru_RU
dc.date.issued	2023	ru_RU
dc.identifier.citation	Kuptsova A.M. Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility /A.M. Kuptsova, L.I. Khisamieva, L.I. Faskhutdinov, R.R. Shakirov,N.I. Ziyatdinova, T.L. Zefirov // Biophysical Reviews. - 2023. - Vol. 15. - p. 1461-1462.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=290414	ru_RU
dc.description.abstract	Biophysical Journal	ru_RU
dc.description.abstract	Hyperpolarization-activated cyclic nucleotide-regulated channels (HCN4) are key membrane proteins involved in the initiation and regulation of heartbeat. The pacemaker cells in the sinoatrial node generate the electrical impulse that underlies the contraction of atrial and ventricular cardiomyocytes. HCN4 channels contribute to the control of resting membrane potential and rhythmic activity of excitable cells expressing these channels. In addition to abundant expression in the pacing and conduction system, the membrane of adult rat working myocardium cells is characterized by low levels of HCN channels. However, in the early embryonic stages, HCN4 channels is abundantly transcribed throughout the heart and makes an important role in ventricular myocyte automatism triggered by If. By birth, HCN4 channels transcription is suppressed in working-type cardiomyocytes and remains at low levels in the adult body, which prevents pathological remodeling of the heart.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Pacemaker currents	ru_RU
dc.subject	3-weekold rat?s	ru_RU
dc.subject	atrial myocardial contractility	ru_RU
dc.title	Pacemaker currents are involved in the regulation of 3-weekold rat's atrial myocardial contractility	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU