| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2024 |
| Язык | английский |
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Кубышева Наиля Исхаковна, автор
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Novikov Dmitry , автор
Novikov Viktor , автор
Perenkov Alexei , автор
Shumilova Svetlana , автор
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| Библиографическое описание на языке оригинала |
Novikov, D. V., Perenkov, A. D., Shumilova, S. V., Kubysheva, N. I., & Novikov, V. V. (2024). CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study). Molecular Biology Reports, 51(1), 1-8. |
| Аннотация |
Molecular Biology Reports |
| Ключевые слова |
CD38; mRNA expression; single nucleotide polymorphism; colorectal cancer |
| Название журнала |
Molecular Biology Reports
|
| URL |
https://link.springer.com/article/10.1007/s11033-023-09034-8 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=294010 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Кубышева Наиля Исхаковна |
ru_RU |
| dc.contributor.author |
Novikov Dmitry |
ru_RU |
| dc.contributor.author |
Novikov Viktor |
ru_RU |
| dc.contributor.author |
Perenkov Alexei |
ru_RU |
| dc.contributor.author |
Shumilova Svetlana |
ru_RU |
| dc.date.accessioned |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2024 |
ru_RU |
| dc.identifier.citation |
Novikov, D. V., Perenkov, A. D., Shumilova, S. V., Kubysheva, N. I., & Novikov, V. V. (2024). CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study). Molecular Biology Reports, 51(1), 1-8. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=294010 |
ru_RU |
| dc.description.abstract |
Molecular Biology Reports |
ru_RU |
| dc.description.abstract |
Background Genetic variations in immune signaling genes may have regulatory effect on phenotypic heterogeneity of immune cells and immune functions, hence promoting tumor growth.
Purpose We compared the frequencies of potentially functional CD38 gene single nucleotide polymorphisms rs1130169 (T>C) in 86 healthy controls and 90 colorectal cancer (CRC) cases to assess their association with cancer risk and CD38 gene expression.
Results The association between allele C rs1130169 and CRC risk was observed. Allele C was also significantly correlated with an increased CD38 mRNA level and CD38 positive cell percentages in peripheral blood of healthy controls that could be a possible explanation for CRC risk in C allele carriers. In peripheral blood of CRC patients CD38 mRNA and serum soluble CD38 protein levels significantly differed from those in healthy controls. Calculation of the CD38 full-length and with the third exon deletion mRNA ratio in corresponding samples showed that the mRNA isoform ratio was significantly higher in CRC cases than in controls. It suggests that alternative splicing regulates elevation of CD38 full-length mRNA level in peripheral blood of CRC patients. We also have observed higher expression levels of CD38 full-length mRNA in peripheral blood of CRC patients with lymph node metastases compared to patients without metastases.
Conclusion This study indicated biological significance of rs1130169 variations that can alter differences in CRC risk by regulating CD38 gene expression.
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ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
CD38 gene polymorphism rs1130169 contribution to the increased gene expression and risk of colorectal cancer (pilot study) |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
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