КФУ. Карточка публикации. New Polymorph of β-Cyclodextrin with a Higher Bioavailability

КАЗАНСКИЙ
ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ

RUS

- EN
- 中文
- ES

NEW POLYMORPH OF β-CYCLODEXTRIN WITH A HIGHER BIOAVAILABILITY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2024

Язык

английский

Авторы, сотрудники КФУ

Балахонцев Илья Сергеевич, автор

Гатиатулин Аскар Камилевич, автор

Горбачук Валерий Виленович, автор

Зиганшин Марат Ахмедович, автор

Авторы, студенты КФУ

Талашманова Софья Михайловна, автор

Библиографическое описание на языке оригинала

Gatiatulin, A.K.; Balakhontsev, I.S.; Talashmanova, S.M.; Ziganshin, M.A.; Gorbatchuk, V.V. New Polymorph of β-Cyclodextrin with a Higher Bioavailability. Chemistry 2024, 6, 51-61. https://doi.org/10.3390/chemistry6010003

Аннотация

A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy, and thermal analysis. The solution enthalpy and time of dissolution in water were determined using solution calorimetry for this polymorph and compared with those of the dried commercial form of β-cyclodextrin (polymorph I), its amorphous form, and 2-hydroxypropyl-β-cyclodextrin. The specific heat capacities of polymorphs I and III were determined using differential scanning calorimetry across a wide range of temperatures, providing enthalpy and Gibbs energy values for the polymorphic transition at 298 K. The affinities of polymorph III and 2-hydroxypropyl-β-cyclodextrin for water were characterized by determining their hydration isotherms, which provided values of hydration Gibbs energy. Being energy-rich, the new-found polymorph of β-cyclodextrin has a significantly higher dissolution rate and an increased affinity for water compared with the dried commercial form of β-cyclodextrin. These properties render the new polymorph promising in industrial applications for guest inclusion in aqueous solutions and pastes, and may be a desirable alternative for water-soluble β-cyclodextrin derivatives.

Ключевые слова

beta-cyclodextrin, polymorphism, bioavailability, polymorphic transition, dissolution rate

Название журнала

Chemistry

URL

https://www.mdpi.com/2624-8549/6/1/3

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=296196

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Балахонцев Илья Сергеевич	ru_RU
dc.contributor.author	Гатиатулин Аскар Камилевич	ru_RU
dc.contributor.author	Горбачук Валерий Виленович	ru_RU
dc.contributor.author	Зиганшин Марат Ахмедович	ru_RU
dc.contributor.author	Талашманова Софья Михайловна	ru_RU
dc.date.accessioned	2024-01-01T00:00:00Z	ru_RU
dc.date.available	2024-01-01T00:00:00Z	ru_RU
dc.date.issued	2024	ru_RU
dc.identifier.citation	Gatiatulin, A.K.; Balakhontsev, I.S.; Talashmanova, S.M.; Ziganshin, M.A.; Gorbatchuk, V.V. New Polymorph of β-Cyclodextrin with a Higher Bioavailability. Chemistry 2024, 6, 51-61. https://doi.org/10.3390/chemistry6010003	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=296196	ru_RU
dc.description.abstract	Chemistry	ru_RU
dc.description.abstract	A new polymorph of anhydrous β-cyclodextrin (polymorph III) was obtained and characterized for the first time using powder X-ray diffraction, infrared spectroscopy, and thermal analysis. The solution enthalpy and time of dissolution in water were determined using solution calorimetry for this polymorph and compared with those of the dried commercial form of β-cyclodextrin (polymorph I), its amorphous form, and 2-hydroxypropyl-β-cyclodextrin. The specific heat capacities of polymorphs I and III were determined using differential scanning calorimetry across a wide range of temperatures, providing enthalpy and Gibbs energy values for the polymorphic transition at 298 K. The affinities of polymorph III and 2-hydroxypropyl-β-cyclodextrin for water were characterized by determining their hydration isotherms, which provided values of hydration Gibbs energy. Being energy-rich, the new-found polymorph of β-cyclodextrin has a significantly higher dissolution rate and an increased affinity for water compared with the dried commercial form of β-cyclodextrin. These properties render the new polymorph promising in industrial applications for guest inclusion in aqueous solutions and pastes, and may be a desirable alternative for water-soluble β-cyclodextrin derivatives.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	beta-cyclodextrin	ru_RU
dc.subject	polymorphism	ru_RU
dc.subject	bioavailability	ru_RU
dc.subject	polymorphic transition	ru_RU
dc.subject	dissolution rate	ru_RU
dc.title	New Polymorph of β-Cyclodextrin with a Higher Bioavailability	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU