КФУ. Карточка публикации. Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity

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SYNTHESIS AND STRUCTURE OF DIMEPHOSPHONE PYRIDINOYLHYDRAZONES WITH ANTIMYCOBACTERIAL ACTIVITY

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2013

Язык

английский

Авторы, сотрудники КФУ

Кашапов Ленар Рамилович, автор

Другие авторы

Гараев Рамил Суфиахметович, автор

Библиографическое описание на языке оригинала

Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity / B. I. Buzykin, V. N. Nabiullin, V. F. Mironov [et al.] // Pharmaceutical Chemistry Journal. – 2013. – Vol. 47, No. 1. – P. 35-39. – DOI 10.1007/s11094-013-0891-8. – EDN RFGJVV.

Аннотация

Nicotinoyl- and isonicotinoylhydrazones of 2-dimethoxyphosphoryl-2- methylpentan-4-one (the active ingredient of the medicinal preparation Dimephosphone) were synthesized. It was shown that crystals of both hydrazones contained a single spatial form of the EC=N isomer. The dimephosphone pyridinoylhydrazones existed in slightly polar and polar solvents as a mixture of two amide conformers of a single EC=N isomer. This was due to hindered rotation of the molecular fragments around the (O=)C-N amide bond. The ratio of conformers was determined by the solvent and the time of solution preparation. Both hydrazones possessed low toxicity and high antimycobacterial activity. ? 2013 Springer Science+Business Media New York.

Ключевые слова

AMIDE CONFORMERS, ANTITUBERCULOSIS ACTIVITY, BIOLOGICAL ACTIVITY, DIMEPHOSPHONE ISO-NICOTINOYLHYDRAZONE, DIMEPHOSPHONE NICOTINOYLHYDRAZONE, DIMEPHOSPHONE PYRIDINOYLHYDRAZONES, GEOMETRIC ISOMERS, IR SPECTROSCOPY, NMR SPECTROSCOPY, STRUCTURE OF ACYLHYDRAZONES, TOXICITY

Название журнала

Pharmaceutical Chemistry Journal

URL

https://link.springer.com/article/10.1007/s11094-013-0891-8

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https://repository.kpfu.ru/?p_id=296901

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Кашапов Ленар Рамилович	ru_RU
dc.contributor.author	Гараев Рамил Суфиахметович	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity / B. I. Buzykin, V. N. Nabiullin, V. F. Mironov [et al.] // Pharmaceutical Chemistry Journal. – 2013. – Vol. 47, No. 1. – P. 35-39. – DOI 10.1007/s11094-013-0891-8. – EDN RFGJVV.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=296901	ru_RU
dc.description.abstract	Pharmaceutical Chemistry Journal	ru_RU
dc.description.abstract	Nicotinoyl- and isonicotinoylhydrazones of 2-dimethoxyphosphoryl-2- methylpentan-4-one (the active ingredient of the medicinal preparation Dimephosphone) were synthesized. It was shown that crystals of both hydrazones contained a single spatial form of the EC=N isomer. The dimephosphone pyridinoylhydrazones existed in slightly polar and polar solvents as a mixture of two amide conformers of a single EC=N isomer. This was due to hindered rotation of the molecular fragments around the (O=)C-N amide bond. The ratio of conformers was determined by the solvent and the time of solution preparation. Both hydrazones possessed low toxicity and high antimycobacterial activity. ? 2013 Springer Science+Business Media New York.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	AMIDE CONFORMERS	ru_RU
dc.subject	ANTITUBERCULOSIS ACTIVITY	ru_RU
dc.subject	BIOLOGICAL ACTIVITY	ru_RU
dc.subject	DIMEPHOSPHONE ISO-NICOTINOYLHYDRAZONE	ru_RU
dc.subject	DIMEPHOSPHONE NICOTINOYLHYDRAZONE	ru_RU
dc.subject	DIMEPHOSPHONE PYRIDINOYLHYDRAZONES	ru_RU
dc.subject	GEOMETRIC ISOMERS	ru_RU
dc.subject	IR SPECTROSCOPY	ru_RU
dc.subject	NMR SPECTROSCOPY	ru_RU
dc.subject	STRUCTURE OF ACYLHYDRAZONES	ru_RU
dc.subject	TOXICITY	ru_RU
dc.title	Synthesis and structure of dimephosphone pyridinoylhydrazones with antimycobacterial activity	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU