КФУ. Карточка публикации. Dimephosphone analogs: A pharmacological aspect

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DIMEPHOSPHONE ANALOGS: A PHARMACOLOGICAL ASPECT

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Язык

английский

Авторы, сотрудники КФУ

Кашапов Ленар Рамилович, автор

Библиографическое описание на языке оригинала

Dimephosphone analogs: A pharmacological aspect / V. F. Mironov, B. I. Buzykin, D. A. Tatarinov [et al.] // Russian Chemical Bulletin. – 2014. – Vol. 63, No. 9. – P. 2114-2125. – DOI 10.1007/s11172-014-0708-2. – EDN UGGDMR.

Аннотация

We studied some pharmacological properties of dimephosphone P - C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P - O - C fragments in dialkyl (2-methyl-4-oxopent-2-yl)phosphonates with the P - C ones on going to dialkyl-(2-methyl-4-oxopent-2-yl)phosphine oxides results in a dramatic decrease in the acute toxicity of the latter to warmblooded animals. The toxicities of dimephosphone aza analogs and (γ-oxoalkyl)phosphine oxides under study depend on the nature of aza fragment introduced instead of the oxygen atom. Dimephosphone pyridinoylhydrazones were found to exhibit a high antiinflammatory activity, which increases the interest for this type compounds as promising tuberculostatics.

Ключевые слова

4-NITROBENZHYDRAZIDE, ACUTE TOXICITY, ACYL HYDRAZONE, ANTI-INFLAMMATORY ACTIVITY, ANTITUBERCULOUS ACTIVITY, AROYL HYDRAZONE, BENZHYDRAZIDE, BIOACTIVITY, DIMEPHOSPHONE, DIMETHYL (2-METHYL-4-OXOPENT-2-YL)PHOSPHONATE, ISONIAZIDE, ISONICOTINOYL HYDRAZONE, NICOTINIC ACID HYDRAZIDE, NICOTINOYL HYDRAZONE, OXIME, PHOSPHINE OXIDE, PYRIDINOYL HYDRAZONE

Название журнала

Russian Chemical Bulletin

URL

https://link.springer.com/article/10.1007/s11172-014-0708-2

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https://repository.kpfu.ru/?p_id=296902

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Кашапов Ленар Рамилович	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Dimephosphone analogs: A pharmacological aspect / V. F. Mironov, B. I. Buzykin, D. A. Tatarinov [et al.] // Russian Chemical Bulletin. – 2014. – Vol. 63, No. 9. – P. 2114-2125. – DOI 10.1007/s11172-014-0708-2. – EDN UGGDMR.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=296902	ru_RU
dc.description.abstract	Russian Chemical Bulletin	ru_RU
dc.description.abstract	We studied some pharmacological properties of dimephosphone P - C and aza analogs, viz., dimethyl (2-methyl-4-oxopent-2-yl)phosphonate, which is one of the first organophosphorus drugs having no anticholinesterase activity. Replacement of two P - O - C fragments in dialkyl (2-methyl-4-oxopent-2-yl)phosphonates with the P - C ones on going to dialkyl-(2-methyl-4-oxopent-2-yl)phosphine oxides results in a dramatic decrease in the acute toxicity of the latter to warmblooded animals. The toxicities of dimephosphone aza analogs and (γ-oxoalkyl)phosphine oxides under study depend on the nature of aza fragment introduced instead of the oxygen atom. Dimephosphone pyridinoylhydrazones were found to exhibit a high antiinflammatory activity, which increases the interest for this type compounds as promising tuberculostatics.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	4-NITROBENZHYDRAZIDE	ru_RU
dc.subject	ACUTE TOXICITY	ru_RU
dc.subject	ACYL HYDRAZONE	ru_RU
dc.subject	ANTI-INFLAMMATORY ACTIVITY	ru_RU
dc.subject	ANTITUBERCULOUS ACTIVITY	ru_RU
dc.subject	AROYL HYDRAZONE	ru_RU
dc.subject	BENZHYDRAZIDE	ru_RU
dc.subject	BIOACTIVITY	ru_RU
dc.subject	DIMEPHOSPHONE	ru_RU
dc.subject	DIMETHYL (2-METHYL-4-OXOPENT-2-YL)PHOSPHONATE	ru_RU
dc.subject	ISONIAZIDE	ru_RU
dc.subject	ISONICOTINOYL HYDRAZONE	ru_RU
dc.subject	NICOTINIC ACID HYDRAZIDE	ru_RU
dc.subject	NICOTINOYL HYDRAZONE	ru_RU
dc.subject	OXIME	ru_RU
dc.subject	PHOSPHINE OXIDE	ru_RU
dc.subject	PYRIDINOYL HYDRAZONE	ru_RU
dc.title	Dimephosphone analogs: A pharmacological aspect	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU