| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2024 |
| Язык | английский |
|
Гнездилов Олег Иванович, автор
|
| Библиографическое описание на языке оригинала |
Sautina N.V. Study of self-organization and structural phase transitions in water /AOT / isopropyl myristate biocompatible system/ N.V. Sautina, O.I. Gnezdilov, A.T. Gubaidullin, Yu.G. Galyametdinov// Journal of Molecular Liquids. -2024. – V.407. – 125193. |
| Аннотация |
This work reports preparation and characterization of biocompatible sodium bis(2-ethylhexyl) sulfosuccinate
(AOT) / water/ isopropyl myristate (IPM) systems. We studied their ability to form various self-organized
structures such as microemulsions and liquid crystal templates for producing nanoparticles such as drug delivery vehicles, which play an important role in delivery of various substances. We determined concentration and
temperature conditions that allow for forming various structures in this system and characterized the structural
phase transition from the microemulsion to liquid crystalline phase, which is important for delivery of bioactive
compounds. The parameters of the liquid crystalline phase of the water/AOT/isopropyl myristate system were
calculated for the first time in this work. The sizes of microemulsion droplets were determined. To describe
molecular motions in the studied microemulsion, self-diffusion coefficients of each component were measured.
The values of relative diffusion coefficients demonstrated that reverse microemulsions were observed at AOT
concentrations up to 60 % wt. Further increase in surfactant concentration slows down their molecular mobility
and results in formation of aggregates with a bimodal size distribution and a subsequent formation of the
hexagonal liquid crystalline phase. Geometry of the mesophase and its structure were investigated by X-ray
diffraction. The respective phase diagram was plotted and analyzed using the data of polarized light microscopy,
dynamic light scattering, and NMR self-diffusion. In this diagram, the areas corresponding to the microemulsion,
the liquid crystal phase, and the structural phase transition were identified.
The study of the structural phase transition from the microemulsion to liquid crystal will offer a predictive
power for characterizing incorporation of drugs and controlling their delivery to target cells. A deeper understanding of the structural changes is necessary to clearly determine the conditions of drug delivery |
| Ключевые слова |
sodium bis(2-ethylhexyl) sulfosuccinate (AOT), isopropyl myristate, NMR self-diffusion, phase transition, liquid crystal |
| Название журнала |
J MOL LIQ
|
| URL |
https://doi.org/10.1016/j.molliq.2024.125193 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=303873 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Гнездилов Олег Иванович |
ru_RU |
| dc.date.accessioned |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2024 |
ru_RU |
| dc.identifier.citation |
Sautina N.V. Study of self-organization and structural phase transitions in water /AOT / isopropyl myristate biocompatible system/ N.V. Sautina, O.I. Gnezdilov, A.T. Gubaidullin, Yu.G. Galyametdinov// Journal of Molecular Liquids. -2024. – V.407. – 125193. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=303873 |
ru_RU |
| dc.description.abstract |
J MOL LIQ |
ru_RU |
| dc.description.abstract |
This work reports preparation and characterization of biocompatible sodium bis(2-ethylhexyl) sulfosuccinate
(AOT) / water/ isopropyl myristate (IPM) systems. We studied their ability to form various self-organized
structures such as microemulsions and liquid crystal templates for producing nanoparticles such as drug delivery vehicles, which play an important role in delivery of various substances. We determined concentration and
temperature conditions that allow for forming various structures in this system and characterized the structural
phase transition from the microemulsion to liquid crystalline phase, which is important for delivery of bioactive
compounds. The parameters of the liquid crystalline phase of the water/AOT/isopropyl myristate system were
calculated for the first time in this work. The sizes of microemulsion droplets were determined. To describe
molecular motions in the studied microemulsion, self-diffusion coefficients of each component were measured.
The values of relative diffusion coefficients demonstrated that reverse microemulsions were observed at AOT
concentrations up to 60 % wt. Further increase in surfactant concentration slows down their molecular mobility
and results in formation of aggregates with a bimodal size distribution and a subsequent formation of the
hexagonal liquid crystalline phase. Geometry of the mesophase and its structure were investigated by X-ray
diffraction. The respective phase diagram was plotted and analyzed using the data of polarized light microscopy,
dynamic light scattering, and NMR self-diffusion. In this diagram, the areas corresponding to the microemulsion,
the liquid crystal phase, and the structural phase transition were identified.
The study of the structural phase transition from the microemulsion to liquid crystal will offer a predictive
power for characterizing incorporation of drugs and controlling their delivery to target cells. A deeper understanding of the structural changes is necessary to clearly determine the conditions of drug delivery |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
sodium bis(2-ethylhexyl) sulfosuccinate (AOT) |
ru_RU |
| dc.subject |
isopropyl myristate |
ru_RU |
| dc.subject |
NMR self-diffusion |
ru_RU |
| dc.subject |
phase transition |
ru_RU |
| dc.subject |
liquid crystal |
ru_RU |
| dc.title |
Study of self-organization and structural phase transitions in water /AOT /
isopropyl myristate biocompatible system |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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