| Форма представления | Статьи в российских журналах и сборниках |
| Год публикации | 2024 |
| Язык | английский |
|
Рыжкин Сергей Александрович, автор
|
| Библиографическое описание на языке оригинала |
EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT /
T.R. Gaynutdinov, S.A. Ryzhkin, R.F. Shavaliev, K.N. Vagin, Y.A. Kurbangaleev, F.H. Kalimullin, E.M. Plotnikova, A.M. Idrisov, S.E. Ohrimenko, E.N. Mayorova // Extreme Medicine. - 2024. - № 2. - p. 63-71. |
| Аннотация |
The study is relevant due to the fact that the decrease in microbial toxicity observed during the radio-inactivation of microorganisms is accompanied by synthesis of radioprotective substances and exertion of the radioprotective effects associated with administration of such microbial agents to exposed animals. The study was aimed to assess radioprotective efficacy of the exposed Staphylococcus aureus variants. The study showed that the Staphylococcus aureus culture treated with a single dose of gamma radiation (30–40 kGy) ensured protection of 55–66% of the lethally irradiated animals. Multiple exposures of the test microorganism to the gradually increasing doses of gamma radiation induced an even larger increase in radioresistance resulting from the synthesis of endogenic radioprotectors, particularly peroxidase, the antioxidant enzyme, and IL1β cytokine, ensuring interception of the radiation-induced toxic radicals and thereby preventing postexposure pancytopenia in the bone marrow. The experiments involving white mice exposed to the absolutely lethal gamma radiation doses (7.9 Gy, LD100/30) showed that a single subcutaneous administration of the St. aureus radioresistant variant (strain 209R70) in a dose of 2 × 108 bacterial cells per animal 3 days after the exposure ensured the 77.7% survival rate, while 100% of untreated animals died. Based on the findings it was concluded that inclusion of the exposed agents of microbial origin would make it possible to increase the efficacy of the combination radioprotectors. |
| Ключевые слова |
Staphylococcus aureus, gamma rays, radio inactivation, radio modification, laboratory animals, anti-radiation effectiveness |
| Название журнала |
Extreme Medicine (MEDICINE OF EXTREME SITUATIONS)
|
| URL |
https://mes.fmba.press/archive/2024/2/7/abstract?lang=en |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=304069 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Рыжкин Сергей Александрович |
ru_RU |
| dc.date.accessioned |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2024-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2024 |
ru_RU |
| dc.identifier.citation |
EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT /
T.R. Gaynutdinov, S.A. Ryzhkin, R.F. Shavaliev, K.N. Vagin, Y.A. Kurbangaleev, F.H. Kalimullin, E.M. Plotnikova, A.M. Idrisov, S.E. Ohrimenko, E.N. Mayorova // Extreme Medicine. - 2024. - № 2. - p. 63-71. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=304069 |
ru_RU |
| dc.description.abstract |
Extreme Medicine (MEDICINE OF EXTREME SITUATIONS) |
ru_RU |
| dc.description.abstract |
The study is relevant due to the fact that the decrease in microbial toxicity observed during the radio-inactivation of microorganisms is accompanied by synthesis of radioprotective substances and exertion of the radioprotective effects associated with administration of such microbial agents to exposed animals. The study was aimed to assess radioprotective efficacy of the exposed Staphylococcus aureus variants. The study showed that the Staphylococcus aureus culture treated with a single dose of gamma radiation (30–40 kGy) ensured protection of 55–66% of the lethally irradiated animals. Multiple exposures of the test microorganism to the gradually increasing doses of gamma radiation induced an even larger increase in radioresistance resulting from the synthesis of endogenic radioprotectors, particularly peroxidase, the antioxidant enzyme, and IL1β cytokine, ensuring interception of the radiation-induced toxic radicals and thereby preventing postexposure pancytopenia in the bone marrow. The experiments involving white mice exposed to the absolutely lethal gamma radiation doses (7.9 Gy, LD100/30) showed that a single subcutaneous administration of the St. aureus radioresistant variant (strain 209R70) in a dose of 2 × 108 bacterial cells per animal 3 days after the exposure ensured the 77.7% survival rate, while 100% of untreated animals died. Based on the findings it was concluded that inclusion of the exposed agents of microbial origin would make it possible to increase the efficacy of the combination radioprotectors. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Staphylococcus aureus |
ru_RU |
| dc.subject |
gamma rays |
ru_RU |
| dc.subject |
radio inactivation |
ru_RU |
| dc.subject |
radio modification |
ru_RU |
| dc.subject |
laboratory animals |
ru_RU |
| dc.subject |
anti-radiation effectiveness |
ru_RU |
| dc.title |
EVALUATION OF ANTI-RADIATION EFFICACY OF THE STAPHYLOCOCCUS AUREUS-DERIVED THERAPEUTIC AGENT |
ru_RU |
| dc.type |
Статьи в российских журналах и сборниках |
ru_RU |
|
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