| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2026 |
| Язык | английский |
|
Саляхутдинова Шахноза Матмурадовна, автор
Хабирова Алина Ильшатовна, автор
Хисматуллин Рафаэль Рафикович, автор
|
|
Weisel John W., автор
Литвинов Рустем Игоревич, автор
|
|
Саляхутдинова Шахноза Матмурадовна, автор
|
| Библиографическое описание на языке оригинала |
Khismatullin, R. R., Khabirova, A. I., Saliakhutdinova, S. M., Litvinov, R. I., & Weisel, J. W. (2026). Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis. Journal of thrombosis and haemostasis : JTH, S1538-7836(25)00597-5. Advance online publication. https://doi.org/10.1016/j.jtha.2025.09.007 |
| Аннотация |
Background
Contraction of blood clots has multiple pathophysiological implications.
Objectives
To determine whether the initial shape and dimensions of blood clots affect clot contraction.
Methods
Thrombin-induced clots of various sizes were formed in human blood or platelet-rich plasma in a cylinder, cuboid, or flat chamber. Clot shrinkage was tracked photographically. After complete contraction, the physiologically most relevant cylindrical clots of various initial volumes were analyzed with scanning electron microscopy for composition and spatial nonuniformity with the emphasis on compressed polyhedral erythrocytes (polyhedrocytes).
Results
With the same volumes studied, the final extents of contraction of 0.3-mL whole blood clots were shape-dependent, such that flat was more contracted than cylindrical, which was equal to cuboid. Irrespective of the shape, the smaller clots mainly contracted to a larger extent. Unlike whole blood clots, platelet-rich plasma clots contracted independently of the clot volumes and shapes studied, indicating a key role of erythrocytes. The smaller blood clots contained more erythrocytes, especially polyhedrocytes, due to tight packing and a decrease in the intercellular space. The spatial segregation within the larger clots was less marked than in the smaller clots, reflecting incomplete spatial redistribution of blood clot components typical for robust contraction.
Conclusion
Contraction of blood clots depends on their shape and size. The smaller and larger clots have distinct size-dependent rates and extents of contraction as well as degrees of structural nonuniformity, reflecting different spatial gradients of compressive stresses. These findings are relevant to the variable geometry and size of intravascular blood clots and thrombi. |
| Ключевые слова |
blood clot, blood platelets, clot retraction, erythrocytes, thrombosis |
| Название журнала |
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
|
| URL |
https://www.sciencedirect.com/science/article/pii/S1538783625005975 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=321771 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Саляхутдинова Шахноза Матмурадовна |
ru_RU |
| dc.contributor.author |
Хабирова Алина Ильшатовна |
ru_RU |
| dc.contributor.author |
Хисматуллин Рафаэль Рафикович |
ru_RU |
| dc.contributor.author |
Weisel John W. |
ru_RU |
| dc.contributor.author |
Литвинов Рустем Игоревич |
ru_RU |
| dc.contributor.author |
Саляхутдинова Шахноза Матмурадовна |
ru_RU |
| dc.date.accessioned |
2026-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2026-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2026 |
ru_RU |
| dc.identifier.citation |
Khismatullin, R. R., Khabirova, A. I., Saliakhutdinova, S. M., Litvinov, R. I., & Weisel, J. W. (2026). Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis. Journal of thrombosis and haemostasis : JTH, S1538-7836(25)00597-5. Advance online publication. https://doi.org/10.1016/j.jtha.2025.09.007 |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=321771 |
ru_RU |
| dc.description.abstract |
JOURNAL OF THROMBOSIS AND HAEMOSTASIS |
ru_RU |
| dc.description.abstract |
Background
Contraction of blood clots has multiple pathophysiological implications.
Objectives
To determine whether the initial shape and dimensions of blood clots affect clot contraction.
Methods
Thrombin-induced clots of various sizes were formed in human blood or platelet-rich plasma in a cylinder, cuboid, or flat chamber. Clot shrinkage was tracked photographically. After complete contraction, the physiologically most relevant cylindrical clots of various initial volumes were analyzed with scanning electron microscopy for composition and spatial nonuniformity with the emphasis on compressed polyhedral erythrocytes (polyhedrocytes).
Results
With the same volumes studied, the final extents of contraction of 0.3-mL whole blood clots were shape-dependent, such that flat was more contracted than cylindrical, which was equal to cuboid. Irrespective of the shape, the smaller clots mainly contracted to a larger extent. Unlike whole blood clots, platelet-rich plasma clots contracted independently of the clot volumes and shapes studied, indicating a key role of erythrocytes. The smaller blood clots contained more erythrocytes, especially polyhedrocytes, due to tight packing and a decrease in the intercellular space. The spatial segregation within the larger clots was less marked than in the smaller clots, reflecting incomplete spatial redistribution of blood clot components typical for robust contraction.
Conclusion
Contraction of blood clots depends on their shape and size. The smaller and larger clots have distinct size-dependent rates and extents of contraction as well as degrees of structural nonuniformity, reflecting different spatial gradients of compressive stresses. These findings are relevant to the variable geometry and size of intravascular blood clots and thrombi. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
blood clot |
ru_RU |
| dc.subject |
blood platelets |
ru_RU |
| dc.subject |
clot retraction |
ru_RU |
| dc.subject |
erythrocytes |
ru_RU |
| dc.subject |
thrombosis |
ru_RU |
| dc.title |
Shapes and dimensions of blood clots affect the rate and extent of platelet-driven clot contraction and determine the outcomes of thrombosis |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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