| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2025 |
| Язык | английский |
|
Кубышева Наиля Исхаковна, автор
|
|
Eliseeva Tatyana , автор
Geppe Natalia , автор
Karpenko Maxim , автор
Khaletskaya Olga , автор
Khramova Regina , автор
Krasilnikova Svetlana , автор
Ovsyannikov Dmitry , автор
Tush Elena , автор
|
| Библиографическое описание на языке оригинала |
Khramova R. N., Tush E. V., Eliseeva T. I., Ovsyannikov D. Y., Krasilnikova S. V., Karpenko M. A., Geppe N. A., Kubysheva N. I., Khaletskaya O. V. (2025). Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma. Exploration of Medicine, 6, 1001338. |
| Аннотация |
Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction.
Methods: A single-center observational cross-sectional pilot study was conducted. Eighty-six patients with BA aged from 8 to 17 years were studied. Anthropometric and spirometric parameters and IL-6, IL-18 levels were assessed. The study participants were divided into 2 groups: 1—patients with normal body weight (BW), 2—overweight/obese.
Results: The serum levels of IL-6 and IL-18 were statistically significantly higher in overweight/obese patients than in normal BW patients, being 1.18 [0.10; 3.27] pg/mL vs. 0.52 [0.10; 1.34] pg/mL, P = 0.036 and 251.0 [207.0; 346.0] pg/mL vs. 208.0 [134.0; 293.0] pg/mL, P = 0.012, respectively. Statistically significant direct correlations of IL-6 and IL-18 with z BMI were obtained in the total group: R = 0.35, P = 0.001; R = 0.37, P = 0.002, respectively. In the overweight/obese group, IL-6 and IL-18 levels were statistically significantly higher in patients with obstruction [z forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < –1.645 z] than in patients without obstruction (z FEV1/FVC > –1.645 z), respectively: 1.74 [1.10; 5.41] pg/mL vs. 0.59 [0.50; 1.48] pg/mL, P = 0.026 for IL-6 and 298.50 [207.00; 425.00] pg/mL vs. 234.50 [207.00; 300.00] pg/mL, P = 0.046 for IL-18.
Conclusions: In patients with BA and overweight/obese, but not in patients with BA and normal BW, the presence of bronchial obstruction is associated with higher serum levels of IL-6, IL-18. This may indicate the involvement of these ILs in the genesis of bronchial obstruction in patients with BA and overweight/obese. |
| Ключевые слова |
Asthma, children, overweight, obesity, IL-6, IL-18 |
| Название журнала |
Exploration of Medicine
|
| URL |
https://www.explorationpub.com/Journals/em/Article/1001338 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=322044 |
| Файлы ресурса | |
|
|
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Кубышева Наиля Исхаковна |
ru_RU |
| dc.contributor.author |
Eliseeva Tatyana |
ru_RU |
| dc.contributor.author |
Geppe Natalia |
ru_RU |
| dc.contributor.author |
Karpenko Maxim |
ru_RU |
| dc.contributor.author |
Khaletskaya Olga |
ru_RU |
| dc.contributor.author |
Khramova Regina |
ru_RU |
| dc.contributor.author |
Krasilnikova Svetlana |
ru_RU |
| dc.contributor.author |
Ovsyannikov Dmitry |
ru_RU |
| dc.contributor.author |
Tush Elena |
ru_RU |
| dc.date.accessioned |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2025 |
ru_RU |
| dc.identifier.citation |
Khramova R. N., Tush E. V., Eliseeva T. I., Ovsyannikov D. Y., Krasilnikova S. V., Karpenko M. A., Geppe N. A., Kubysheva N. I., Khaletskaya O. V. (2025). Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma. Exploration of Medicine, 6, 1001338. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=322044 |
ru_RU |
| dc.description.abstract |
Exploration of Medicine |
ru_RU |
| dc.description.abstract |
Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction.
Methods: A single-center observational cross-sectional pilot study was conducted. Eighty-six patients with BA aged from 8 to 17 years were studied. Anthropometric and spirometric parameters and IL-6, IL-18 levels were assessed. The study participants were divided into 2 groups: 1—patients with normal body weight (BW), 2—overweight/obese.
Results: The serum levels of IL-6 and IL-18 were statistically significantly higher in overweight/obese patients than in normal BW patients, being 1.18 [0.10; 3.27] pg/mL vs. 0.52 [0.10; 1.34] pg/mL, P = 0.036 and 251.0 [207.0; 346.0] pg/mL vs. 208.0 [134.0; 293.0] pg/mL, P = 0.012, respectively. Statistically significant direct correlations of IL-6 and IL-18 with z BMI were obtained in the total group: R = 0.35, P = 0.001; R = 0.37, P = 0.002, respectively. In the overweight/obese group, IL-6 and IL-18 levels were statistically significantly higher in patients with obstruction [z forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < –1.645 z] than in patients without obstruction (z FEV1/FVC > –1.645 z), respectively: 1.74 [1.10; 5.41] pg/mL vs. 0.59 [0.50; 1.48] pg/mL, P = 0.026 for IL-6 and 298.50 [207.00; 425.00] pg/mL vs. 234.50 [207.00; 300.00] pg/mL, P = 0.046 for IL-18.
Conclusions: In patients with BA and overweight/obese, but not in patients with BA and normal BW, the presence of bronchial obstruction is associated with higher serum levels of IL-6, IL-18. This may indicate the involvement of these ILs in the genesis of bronchial obstruction in patients with BA and overweight/obese. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Asthma |
ru_RU |
| dc.subject |
children |
ru_RU |
| dc.subject |
overweight |
ru_RU |
| dc.subject |
obesity |
ru_RU |
| dc.subject |
IL-6 |
ru_RU |
| dc.subject |
IL-18 |
ru_RU |
| dc.title |
Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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