| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2025 |
| Язык | русский |
|
Кубышева Наиля Исхаковна, автор
|
|
Eliseeva Tatyana , автор
Geppe Natalia , автор
Gorbunova Ksenia , автор
Khramova Regina , автор
Krasilnikova Svetlana , автор
Krestova Ekaterina , автор
Leontieva Elena , автор
Ovsyannikov Dmitry , автор
|
| Библиографическое описание на языке оригинала |
Krasilnikova S. V., Krestova E. I., Eliseeva T. I., Khramova R. N., Gorbunova K. V., Leontieva E. A., Ovsyannikov D.Yu., Geppe N.A., Kubysheva N. I. (2025). Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa. Exploration of Medicine, 6, 1001306. |
| Аннотация |
Aim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in children and adolescents with a combined course of bronchial asthma (BA) and allergic rhinitis (AR) in the absence or presence of polyposis and hypertrophy of the SM.
Methods: A single-centre observational cross-sectional pilot study was conducted. 93 patients with BA aged 8 to 17 years were studied. Total Nasal Symptom Score (TNSS), sinonasal symptoms (SNOT-22), and peak nasal inspiratory flow (PNIF) were assessed. Concentrations of eosinophil cationic protein (ECP), interleukin 4 (IL-4), IL-1, total immunoglobulin E (IgE), and vascular endothelial growth factor (VEGF) in nasal secretions were determined.
Results: The levels of ECP, IL-4, and IL-1 in nasal secretions were statistically significantly higher in patients with the presence of polyposis and hypertrophic SM than in those without, amounting to 83.1 [31.4; 166.8] ng/mL for ECP vs. 29.5 [5.3; 49.9] ng/mL, P < 0.001, for IL-4 174.6 [68.6; 325.5] pg/mL vs. 79.5 [42.8; 146.01] pg/mL, P = 0.004, for IL-1 98.7 [33.7; 267.5] pg/mL and 48.8 [9.01; 108.2] pg/mL, P = 0.025. There were no statistically significant differences in IgE and VEGF levels in nasal secretions, all P > 0.05. Parameters such as ECP, IL-4, and IL-1 were found to be significant predictors of polyposis and hypertrophy in the formation of SM.
Conclusions: In patients with a combined course of BA and AR, the presence of polyposis and hypertrophy of SM is associated with higher levels of ECP, IL-4, and IL-1 in nasal secretion. This may indicate that pathological remodelling of SM is associated with both the intensity of allergic inflammation and its relationship with local activation of innate immunity. |
| Ключевые слова |
Bronchial asthma, allergic rhinitis, children, adolescents, polyps, biomarkers |
| Название журнала |
Exploration of Medicine
|
| URL |
https://www.explorationpub.com/Journals/em/Article/1001306 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=322045 |
| Файлы ресурса | |
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Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Кубышева Наиля Исхаковна |
ru_RU |
| dc.contributor.author |
Eliseeva Tatyana |
ru_RU |
| dc.contributor.author |
Geppe Natalia |
ru_RU |
| dc.contributor.author |
Gorbunova Ksenia |
ru_RU |
| dc.contributor.author |
Khramova Regina |
ru_RU |
| dc.contributor.author |
Krasilnikova Svetlana |
ru_RU |
| dc.contributor.author |
Krestova Ekaterina |
ru_RU |
| dc.contributor.author |
Leontieva Elena |
ru_RU |
| dc.contributor.author |
Ovsyannikov Dmitry |
ru_RU |
| dc.date.accessioned |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2025-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2025 |
ru_RU |
| dc.identifier.citation |
Krasilnikova S. V., Krestova E. I., Eliseeva T. I., Khramova R. N., Gorbunova K. V., Leontieva E. A., Ovsyannikov D.Yu., Geppe N.A., Kubysheva N. I. (2025). Inflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa. Exploration of Medicine, 6, 1001306. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=322045 |
ru_RU |
| dc.description.abstract |
Exploration of Medicine |
ru_RU |
| dc.description.abstract |
Aim: The pathogenetic mechanisms and predictors of the development of polyposis and hypertrophy of the sinonasal mucosa (SM) in patients with chronic allergic airway inflammation have not been clearly established. The concentration of inflammatory biomarkers in nasal secretions was determined in children and adolescents with a combined course of bronchial asthma (BA) and allergic rhinitis (AR) in the absence or presence of polyposis and hypertrophy of the SM.
Methods: A single-centre observational cross-sectional pilot study was conducted. 93 patients with BA aged 8 to 17 years were studied. Total Nasal Symptom Score (TNSS), sinonasal symptoms (SNOT-22), and peak nasal inspiratory flow (PNIF) were assessed. Concentrations of eosinophil cationic protein (ECP), interleukin 4 (IL-4), IL-1, total immunoglobulin E (IgE), and vascular endothelial growth factor (VEGF) in nasal secretions were determined.
Results: The levels of ECP, IL-4, and IL-1 in nasal secretions were statistically significantly higher in patients with the presence of polyposis and hypertrophic SM than in those without, amounting to 83.1 [31.4; 166.8] ng/mL for ECP vs. 29.5 [5.3; 49.9] ng/mL, P < 0.001, for IL-4 174.6 [68.6; 325.5] pg/mL vs. 79.5 [42.8; 146.01] pg/mL, P = 0.004, for IL-1 98.7 [33.7; 267.5] pg/mL and 48.8 [9.01; 108.2] pg/mL, P = 0.025. There were no statistically significant differences in IgE and VEGF levels in nasal secretions, all P > 0.05. Parameters such as ECP, IL-4, and IL-1 were found to be significant predictors of polyposis and hypertrophy in the formation of SM.
Conclusions: In patients with a combined course of BA and AR, the presence of polyposis and hypertrophy of SM is associated with higher levels of ECP, IL-4, and IL-1 in nasal secretion. This may indicate that pathological remodelling of SM is associated with both the intensity of allergic inflammation and its relationship with local activation of innate immunity. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Bronchial asthma |
ru_RU |
| dc.subject |
allergic rhinitis |
ru_RU |
| dc.subject |
children |
ru_RU |
| dc.subject |
adolescents |
ru_RU |
| dc.subject |
polyps |
ru_RU |
| dc.subject |
biomarkers |
ru_RU |
| dc.title |
nflammatory mediators in nasal secretion in patients with bronchial asthma and allergic rhinitis with or without polyposis and hypertrophic sinonasal mucosa |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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