КФУ. Карточка публикации. Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis

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JOINT TISSUES: CONVERGENCE AND DIVERGENCE OF THE PATHOGENETIC MECHANISMS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2025

Язык

русский

Авторы, сотрудники КФУ

Арлеевская Марина Игоревна, автор

Валеева Анна Рафкатовна, автор

Библиографическое описание на языке оригинала

Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis / M. O. Korovina, A. R. Valeeva, I. F. Akhtyamov [et al.] // International Journal of Molecular Sciences. – 2025. – Vol. 26, No. 17. – P. 8742. – DOI 10.3390/ijms26178742. – EDN ENRGGW.

Аннотация

Rheumatoid arthritis (RA) and osteoarthritis (OA) are frequently occurring multifactorial diseases affecting joints. OA and RA may share not only tissue locations but also some molecular mechanisms. We compared different pathologies: anti-cyclic citrullinated peptide antibody (ACCP)-positive RA—the classical 'antigen-driven' pathology, starting in synovia with no signs of inflammatory process; ACCP-negative RA, starting with synovial inflammation triggered by nonspecific factors, which becomes a chronic process due to inherited innate immune peculiarities; and OA, starting with inadequate chondrocyte functioning and cartilage degradation with inflammation as a driving force. Notable coincidences in RA and OA development were revealed: shared mutations of 29 genes encoding molecules involved in immune-inflammatory processes and in ECM production; unidirectional association of OA and ACCP-negative RA with non-genetic triggers; and overactivation of signaling pathways with the same consequences for RA and OA. Innate and adaptive immune responses were involved in OA development. Similar to that observed in RA, lymphoid nodular aggregates were revealed in 30% of OA synovia. Myeloid, and especially pauci-immune and fibroid synovial pathotypes, are possible in OA. Indistinguishable from that in RA, pannuses were found in OA articular tissues. Thus, these coincidences may be evidence of evolution of some OA variants in RA.

Ключевые слова

Rheumatoid arthritis (RA), osteoarthritis (OA), molecular mechanisms.

Название журнала

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

URL

https://www.mdpi.com/1422-0067/26/17/8742

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https://repository.kpfu.ru/?p_id=324631

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Арлеевская Марина Игоревна	ru_RU
dc.contributor.author	Валеева Анна Рафкатовна	ru_RU
dc.date.accessioned	2025-01-01T00:00:00Z	ru_RU
dc.date.available	2025-01-01T00:00:00Z	ru_RU
dc.date.issued	2025	ru_RU
dc.identifier.citation	Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis / M. O. Korovina, A. R. Valeeva, I. F. Akhtyamov [et al.] // International Journal of Molecular Sciences. – 2025. – Vol. 26, No. 17. – P. 8742. – DOI 10.3390/ijms26178742. – EDN ENRGGW.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=324631	ru_RU
dc.description.abstract	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	ru_RU
dc.description.abstract	Rheumatoid arthritis (RA) and osteoarthritis (OA) are frequently occurring multifactorial diseases affecting joints. OA and RA may share not only tissue locations but also some molecular mechanisms. We compared different pathologies: anti-cyclic citrullinated peptide antibody (ACCP)-positive RA—the classical 'antigen-driven' pathology, starting in synovia with no signs of inflammatory process; ACCP-negative RA, starting with synovial inflammation triggered by nonspecific factors, which becomes a chronic process due to inherited innate immune peculiarities; and OA, starting with inadequate chondrocyte functioning and cartilage degradation with inflammation as a driving force. Notable coincidences in RA and OA development were revealed: shared mutations of 29 genes encoding molecules involved in immune-inflammatory processes and in ECM production; unidirectional association of OA and ACCP-negative RA with non-genetic triggers; and overactivation of signaling pathways with the same consequences for RA and OA. Innate and adaptive immune responses were involved in OA development. Similar to that observed in RA, lymphoid nodular aggregates were revealed in 30% of OA synovia. Myeloid, and especially pauci-immune and fibroid synovial pathotypes, are possible in OA. Indistinguishable from that in RA, pannuses were found in OA articular tissues. Thus, these coincidences may be evidence of evolution of some OA variants in RA.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Rheumatoid arthritis (RA)	ru_RU
dc.subject	osteoarthritis (OA)	ru_RU
dc.subject	molecular mechanisms.	ru_RU
dc.title	Joint Tissues: Convergence and Divergence of the Pathogenetic Mechanisms of Rheumatoid Arthritis and Osteoarthritis	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU