КФУ. Карточка публикации. Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid

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PHASE-TRANSITION THERMODYNAMICS OF HYDRAZIDE DRUGS: ISONIAZID AND IPRONIAZID

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2026

Язык

английский

Авторы, сотрудники КФУ

Болматенков Дмитрий Николаевич, автор

Низамов Ильяс Ильнарович, автор

Нотфуллин Айрат Альбертович, автор

Соколов Андрей Анатольевич, автор

Соломонов Борис Николаевич, автор

Хисамиев Мансур Булатович, автор

Ягофаров Михаил Искандерович, автор

Библиографическое описание на языке оригинала

Notfullin AA, Bolmatenkov DN, Nizamov II, Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid//THERMOCHIMICA ACTA. - 2026. - Vol.759, Is.. - Art. №180277.

Аннотация

In this work, we provide experimental values of phase transition thermodynamic parameters of two structurally similar drugs, pyridine-4-carbohydrazide (isoniazid) and N'-propan-2-ylpyridine-4-carbohydrazide (iproniazid), in a wide temperature range. Saturated vapor pressures above crystalline phases and sublimation enthalpies were measured using the thermogravimetry-fast scanning calorimetry (TG-FSC). The thermodynamics of fusion between 298.15 K and the melting point Tm was studied by a combination of differential scanning calorimetry (DSC) and solution calorimetry techniques. Heat capacities used for temperature corrections were determined as follows: the values for polymorphic form I of isoniazid and form II of iproniazid were measured by differential scanning calorimetry; supercooled liquid phase heat capacities were obtained using fast scanning calorimetry (FSC); and ideal gas phase heat capacities were calculated using quantum chemistry and statistical thermodynamics. Based on sublimation and melting data, thermodynamic parameters of vaporization were derived. The similarities and differences in phase transition thermodynamic properties of two drugs were discussed applying additivity-based approaches.

Ключевые слова

Phase-transition thermodynamics, Isoniazid, Iproniazid

Название журнала

THERMOCHIMICA ACTA

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https://repository.kpfu.ru/?p_id=325259

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Болматенков Дмитрий Николаевич	ru_RU
dc.contributor.author	Низамов Ильяс Ильнарович	ru_RU
dc.contributor.author	Нотфуллин Айрат Альбертович	ru_RU
dc.contributor.author	Соколов Андрей Анатольевич	ru_RU
dc.contributor.author	Соломонов Борис Николаевич	ru_RU
dc.contributor.author	Хисамиев Мансур Булатович	ru_RU
dc.contributor.author	Ягофаров Михаил Искандерович	ru_RU
dc.date.accessioned	2026-01-01T00:00:00Z	ru_RU
dc.date.available	2026-01-01T00:00:00Z	ru_RU
dc.date.issued	2026	ru_RU
dc.identifier.citation	Notfullin AA, Bolmatenkov DN, Nizamov II, Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid//THERMOCHIMICA ACTA. - 2026. - Vol.759, Is.. - Art. №180277.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=325259	ru_RU
dc.description.abstract	THERMOCHIMICA ACTA	ru_RU
dc.description.abstract	In this work, we provide experimental values of phase transition thermodynamic parameters of two structurally similar drugs, pyridine-4-carbohydrazide (isoniazid) and N'-propan-2-ylpyridine-4-carbohydrazide (iproniazid), in a wide temperature range. Saturated vapor pressures above crystalline phases and sublimation enthalpies were measured using the thermogravimetry-fast scanning calorimetry (TG-FSC). The thermodynamics of fusion between 298.15 K and the melting point Tm was studied by a combination of differential scanning calorimetry (DSC) and solution calorimetry techniques. Heat capacities used for temperature corrections were determined as follows: the values for polymorphic form I of isoniazid and form II of iproniazid were measured by differential scanning calorimetry; supercooled liquid phase heat capacities were obtained using fast scanning calorimetry (FSC); and ideal gas phase heat capacities were calculated using quantum chemistry and statistical thermodynamics. Based on sublimation and melting data, thermodynamic parameters of vaporization were derived. The similarities and differences in phase transition thermodynamic properties of two drugs were discussed applying additivity-based approaches.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Phase-transition thermodynamics	ru_RU
dc.subject	Isoniazid	ru_RU
dc.subject	Iproniazid	ru_RU
dc.title	Phase-transition thermodynamics of hydrazide drugs: Isoniazid and Iproniazid	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU