КФУ. Карточка публикации. Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship

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ANTIFUNGAL ACTIVITY OF OLIGOCHITOSANS (SHORT CHAIN CHITOSANS) AGAINST SOME CANDIDA SPECIES AND CLINICAL ISOLATES OF CANDIDA ALBICANS: MOLECULAR WEIGHT-ACTIVITY RELATIONSHIP

Форма представления

Статьи в российских журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Зеленихин Павел Валерьевич, автор

Другие авторы

S.N. Kulikov; S.A. Lisovskaya;E.A. Bezrodnykh; D.R. Shakirova; I.V. Blagodatskikh; V.E. Tikhonov

Библиографическое описание на языке оригинала

Kulikov, S.N. Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship [Text] / S.N. Kulikov, S.A. Lisovskaya, P.V. Zelenikhin, E.A. Bezrodnykh, D.R. Shakirova, I.V. Blagodatskikh, V.E. Tikhonov // Eur J Med Chem.- 2013.- V.74C.- P.169-178.

Аннотация

Eur J Med Chem

Ключевые слова

Activity, Candida, Chitosan, Cytometry, Hyphae, Oligochitosan, TEM

Название журнала

Eur J Med Chem

URL

http://www.sciencedirect.com/science/article/pii/S0223523413008052

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https://repository.kpfu.ru/?p_id=79006

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Зеленихин Павел Валерьевич	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Kulikov, S.N. Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship [Text] / S.N. Kulikov, S.A. Lisovskaya, P.V. Zelenikhin, E.A. Bezrodnykh, D.R. Shakirova, I.V. Blagodatskikh, V.E. Tikhonov // Eur J Med Chem.- 2013.- V.74C.- P.169-178.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=79006	ru_RU
dc.description.abstract	Eur J Med Chem	ru_RU
dc.description.abstract	Eur J Med Chem	ru_RU
dc.description.abstract	A series of oligochitosans (short chain chitosans) prepared by acidic hydrolysis of chitosan and characterized by their molecular weight, polydispersity and degree of deacetylation were used to determine their anticandidal activities. This study has demonstrated that oligochitosans show a high fungistatic activity (MIC 8-512 μg/ml) against Candida species and clinical isolates of Candida albicans, which are resistant to a series of classic antibiotics. Flow cytometry analysis showed that oligochitosan possessed a high fungicidal activity as well. For the first time it was shown that even sub-MIC oligochitosan concentration suppressed the formation of C. albicans hyphal structures, cause severe cell wall alterations, and altered internal cell structure. These results indicate that oligochitosan should be considered as a possible alternative/additive to known anti-yeast agents in pharmaceutical compositions.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Activity	ru_RU
dc.subject	Candida	ru_RU
dc.subject	Chitosan	ru_RU
dc.subject	Cytometry	ru_RU
dc.subject	Hyphae	ru_RU
dc.subject	Oligochitosan	ru_RU
dc.subject	TEM	ru_RU
dc.title	Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship	ru_RU
dc.type	Статьи в российских журналах и сборниках	ru_RU