КФУ. Карточка публикации. Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target

RUS

- EN
- 中文
- ES

ADAPTATION OF MYCOPLASMAS TO ANTIMICROBIAL AGENTS: ACHOLEPLASMA LAIDLAWII EXTRACELLULAR VESICLES MEDIATE THE EXPORT OF CIPROFLOXACIN AND A MUTANT GENE RELATED TO THE ANTIBIOTIC TARGET

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Трушин Максим Викторович, автор

Библиографическое описание на языке оригинала

Medvedeva, E.S.a , Baranova, N.B.a , Mouzykantov, A.A.a , Grigorieva, T.Y.a , Davydova, M.N.a , Trushin, M.V.ab , Chernova, O.A.ab , Chernov, V.M. Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target // The Scientific World Journal Volume 2014, 2014, Article number 150615

Аннотация

This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes). This study assessed the differences in susceptibility to ciprofloxacin among strains of Acholeplasma laidlawii PG8. The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level. A. laidlawii extracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin. These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations.

Ключевые слова

Acholeplasma laidlawii; antibiotic resistance; article; cell culture; cell vacuole; drug targeting; drug transport; gene mutation; Mycoplasma; mycoplasmosis; nonhuman; nucleotide sequence

Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку

https://repository.kpfu.ru/?p_id=83848

Файлы ресурса

Название файла	Размер (Мб)	Формат
tswj_chernov_2014_150615.pdf	2,52	pdf	посмотреть / скачать

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Трушин Максим Викторович	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Medvedeva, E.S.a , Baranova, N.B.a , Mouzykantov, A.A.a , Grigorieva, T.Y.a , Davydova, M.N.a , Trushin, M.V.ab , Chernova, O.A.ab , Chernov, V.M. Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target // The Scientific World Journal Volume 2014, 2014, Article number 150615	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=83848	ru_RU
dc.description.abstract	This study demonstrated that extracellular membrane vesicles are involved with the development of resistance to fluoroquinolones by mycoplasmas (class Mollicutes). This study assessed the differences in susceptibility to ciprofloxacin among strains of Acholeplasma laidlawii PG8. The mechanisms of mycoplasma resistance to antibiotics may be associated with a mutation in a gene related to the target of quinolones, which could modulate the vesiculation level. A. laidlawii extracellular vesicles mediated the export of the nucleotide sequences of the antibiotic target gene as well as the traffic of ciprofloxacin. These results may facilitate the development of effective approaches to control mycoplasma infections, as well as the contamination of cell cultures and vaccine preparations.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU