КФУ. Карточка публикации. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress

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POLYAMINE MODIFICATION BY ACROLEIN EXCLUSIVELY PRODUCES 1,5-DIAZACYCLOOCTANES: A PREVIOUSLY UNRECOGNIZED MECHANISM FOR ACROLEIN-MEDIATED OXIDATIVE STRESS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Курбангалиева Альмира Рафаэловна, автор

Другие авторы

A. Tsutsui; R. Imamak; S. Kitazume; S. Hanashima; Y. Yamaguchi; M. Kaneda; S. Oishi; N. Fujii; N. Taniguchi

Библиографическое описание на языке оригинала

A. Tsutsui, R. Imamaki, S. Kitazume, S. Hanashima, Y. Yamaguchi, M. Kaneda, S. Oishi, N. Fujii, A. Kurbangalieva, N. Taniguchi, K. Tanaka. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress // Org. Biomol. Chem. 2014. V. 12. № 28. P. 5151-5157.

Аннотация

Acrolein, a toxic unsaturated aldehyde generated as a result of oxidative stress, readily reacts with a variety of nucleophilic biomolecules. Polyamines, which produced acrolein in the presence of amine oxidase, were then found to react with acrolein to produce 1,5-diazacyclooctane, a previously unrecognized but significant downstream product of oxidative stress. Although diazacyclooctane formation effectively neutralized acrolein toxicity, the diazacyclooctane hydrogel produced through a sequential diazacyclooctane polymerization reaction was highly cytotoxic. This study suggests that diazacyclooctane formation is involved in the mechanism underlying acrolein-mediated oxidative stress.

Ключевые слова

acrolein, oxidative stress, polyamine, 1,5-diazacyclooctanes

Название журнала

Org. Biomol. Chem.

URL

http://pubs.rsc.org/en/content/articlelanding/2014/ob/c4ob00761a#divAbstract

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https://repository.kpfu.ru/?p_id=87123

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Курбангалиева Альмира Рафаэловна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	A. Tsutsui, R. Imamaki, S. Kitazume, S. Hanashima, Y. Yamaguchi, M. Kaneda, S. Oishi, N. Fujii, A. Kurbangalieva, N. Taniguchi, K. Tanaka. Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress // Org. Biomol. Chem. 2014. V. 12. № 28. P. 5151-5157.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=87123	ru_RU
dc.description.abstract	Org. Biomol. Chem.	ru_RU
dc.description.abstract	Acrolein, a toxic unsaturated aldehyde generated as a result of oxidative stress, readily reacts with a variety of nucleophilic biomolecules. Polyamines, which produced acrolein in the presence of amine oxidase, were then found to react with acrolein to produce 1,5-diazacyclooctane, a previously unrecognized but significant downstream product of oxidative stress. Although diazacyclooctane formation effectively neutralized acrolein toxicity, the diazacyclooctane hydrogel produced through a sequential diazacyclooctane polymerization reaction was highly cytotoxic. This study suggests that diazacyclooctane formation is involved in the mechanism underlying acrolein-mediated oxidative stress.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	oxidative stress	ru_RU
dc.subject	polyamine	ru_RU
dc.subject	1	ru_RU
dc.subject	5-diazacyclooctanes	ru_RU
dc.title	Polyamine modification by acrolein exclusively produces 1,5-diazacyclooctanes: A previously unrecognized mechanism for acrolein-mediated oxidative stress	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU