КФУ. Карточка публикации. Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging.

КАЗАНСКИЙ
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UNIVERSAL INTERNUCLEOTIDE STATISTICS IN FULL GENOMES: A FOOTPRINT OF THE DNA STRUCTURE AND PACKAGING.

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Каюмов Айрат Рашитович, автор

Другие авторы

Bogachev M. I.; Bunde A.

Библиографическое описание на языке оригинала

Bogachev M. I., Kayumov A. R., Bunde A. Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging? // Plos One. - December 1, 2014. Doi: 10.1371/journal.pone.0112534.

Аннотация

Uncovering the fundamental laws that govern the complex DNA structural organization remains challenging and is largely based upon reconstructions from the primary nucleotide sequences. Here we investigate the distributions of the internucleotide intervals and their persistence properties in complete genomes of various organisms from Archaea and Bacteria to H. Sapiens aiming to reveal the manifestation of the universal DNA architecture. We find that in all considered organisms the internucleotide interval distributions exhibit the same q -exponential form. While in prokaryotes a single q-exponential function makes the best fit, in eukaryotes the PDF contains additionally a second q -exponential, which in the human genome makes a perfect approximation over nearly 10 decades. We suggest that this functional form is a footprint of the heterogeneous DNA structure, where the first q-exponential reflects the universal helical pitch that appears both in pro- and eukaryotic DNA, while the second q -exponential is a specific marker of the large-scale eukaryotic DNA organization.

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Название журнала

PLos ONE

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https://repository.kpfu.ru/?p_id=88595

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Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Каюмов Айрат Рашитович	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Bogachev M. I., Kayumov A. R., Bunde A. Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging? // Plos One. - December 1, 2014. Doi: 10.1371/journal.pone.0112534.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=88595	ru_RU
dc.description.abstract	PLos ONE	ru_RU
dc.description.abstract	Uncovering the fundamental laws that govern the complex DNA structural organization remains challenging and is largely based upon reconstructions from the primary nucleotide sequences. Here we investigate the distributions of the internucleotide intervals and their persistence properties in complete genomes of various organisms from Archaea and Bacteria to H. Sapiens aiming to reveal the manifestation of the universal DNA architecture. We find that in all considered organisms the internucleotide interval distributions exhibit the same q -exponential form. While in prokaryotes a single q-exponential function makes the best fit, in eukaryotes the PDF contains additionally a second q -exponential, which in the human genome makes a perfect approximation over nearly 10 decades. We suggest that this functional form is a footprint of the heterogeneous DNA structure, where the first q-exponential reflects the universal helical pitch that appears both in pro- and eukaryotic DNA, while the second q -exponential is a specific marker of the large-scale eukaryotic DNA organization.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Universal internucleotide statistics in full genomes: A footprint of the DNA structure and packaging.	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU