| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2014 |
| Язык | русский |
|
Курбангалиева Альмира Рафаэловна, автор
Маргулис Анна Борисовна, автор
Тризна Елена Юрьевна, автор
|
|
Хоанг Тхи Лиен, автор
|
| Библиографическое описание на языке оригинала |
A. R. Kayumov, E. N. Khakimullina, I. S. Sharafutdinov, E. Y. Trizna, L. Z. Latypova, L. Hoang, A. B. Margulis, M. I. Bogachev, A. R. Kurbangalieva. Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones // J. Antibiot. - 2014. doi: 10.1038/ja.2014.143 (принята в печать) |
| Аннотация |
Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation. Here we investigated the effect of novel synthesized chloro- and bromo-containing 2(5H)-furanones on biofilm formation by B. subtilis. Mucobromic acid (3,4-dibromo-5-hydroxy-2(5H)-furanone) and the two derivatives of mucochloric acid (3,4-dichloro-5-hydroxy-2(5H)-furanone)?F8 and F12?were found to inhibit the growth and to efficiently prevent biofilm formation by B. subtilis. Along with the low production of polysaccharide matrix and repression of the eps operon, strong repression of biofilm-related yqxM also occurred in the presence of furanones. |
| Ключевые слова |
Gram-positive bacteria, 2(5H)-furanones, biofilm formation |
| Название журнала |
The Journal of Antibiotics
|
| URL |
http://www.nature.com/ja/journal/vaop/ncurrent/full/ja2014143a.html |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=88600 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Курбангалиева Альмира Рафаэловна |
ru_RU |
| dc.contributor.author |
Маргулис Анна Борисовна |
ru_RU |
| dc.contributor.author |
Тризна Елена Юрьевна |
ru_RU |
| dc.contributor.author |
Хоанг Тхи Лиен |
ru_RU |
| dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2014 |
ru_RU |
| dc.identifier.citation |
A. R. Kayumov, E. N. Khakimullina, I. S. Sharafutdinov, E. Y. Trizna, L. Z. Latypova, L. Hoang, A. B. Margulis, M. I. Bogachev, A. R. Kurbangalieva. Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones // J. Antibiot. - 2014. doi: 10.1038/ja.2014.143 (принята в печать) |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=88600 |
ru_RU |
| dc.description.abstract |
The Journal of Antibiotics |
ru_RU |
| dc.description.abstract |
Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacterium, is widely used as a model organism for studying biofilm formation. Here we investigated the effect of novel synthesized chloro- and bromo-containing 2(5H)-furanones on biofilm formation by B. subtilis. Mucobromic acid (3,4-dibromo-5-hydroxy-2(5H)-furanone) and the two derivatives of mucochloric acid (3,4-dichloro-5-hydroxy-2(5H)-furanone)?F8 and F12?were found to inhibit the growth and to efficiently prevent biofilm formation by B. subtilis. Along with the low production of polysaccharide matrix and repression of the eps operon, strong repression of biofilm-related yqxM also occurred in the presence of furanones. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Gram-positive bacteria |
ru_RU |
| dc.subject |
2(5H)-furanones |
ru_RU |
| dc.subject |
biofilm formation |
ru_RU |
| dc.title |
Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones. |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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