КФУ. Карточка публикации. T.G. Shutava, R.F. Fakhrullin, Y.M. Lvov, “Spherical and tubule nanocarriers for sustained drug release” Curr. Opin. Pharmacol., 2014, 18, 141

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T.G. SHUTAVA, R.F. FAKHRULLIN, Y.M. LVOV, &LDQUO;SPHERICAL AND TUBULE NANOCARRIERS FOR SUSTAINED DRUG RELEASE&RDQUO; CURR. OPIN. PHARMACOL., 2014, 18, 141&NDASH;148.

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Фахруллин Равиль Фаридович, автор

Библиографическое описание на языке оригинала

T.G. Shutava, R.F. Fakhrullin, Y.M. Lvov, “Spherical and tubule nanocarriers for sustained drug release” Curr. Opin. Pharmacol., 2014, 18, 141–148.

Аннотация

We discuss new trends in Layer-by-Layer (LbL) encapsulation of spherical and tubular cores of 50?150 nm diameter and loaded with drugs. This core size decrease (from few micrometers to a hundred of nanometers) for LbL encapsulation required development of sonication assistant non-washing technique and shell PEGylation to reach high colloidal stability of drug nanocarriers at 2?3 mg/mL concentration in isotonic buffers and serum. For 120?170 nm spherical LbL nanocapsules of low soluble anticancer drugs, polyelectrolyte shell thickness controls drug dissolution. As for nanotube carriers, we concentrated on natural halloysite clay nanotubes as cores for LbL encapsulation that allows high drug loading and sustains its release over tens and hundreds hours. Further drug release prolongation was reached with formation of the tube-end stoppers.

Ключевые слова

Halloysite

URL

http://www.sciencedirect.com/science/article/pii/S1471489214001295

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https://repository.kpfu.ru/?p_id=89852

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Фахруллин Равиль Фаридович	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	T.G. Shutava, R.F. Fakhrullin, Y.M. Lvov, “Spherical and tubule nanocarriers for sustained drug release” Curr. Opin. Pharmacol., 2014, 18, 141–148.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=89852	ru_RU
dc.description.abstract	We discuss new trends in Layer-by-Layer (LbL) encapsulation of spherical and tubular cores of 50?150 nm diameter and loaded with drugs. This core size decrease (from few micrometers to a hundred of nanometers) for LbL encapsulation required development of sonication assistant non-washing technique and shell PEGylation to reach high colloidal stability of drug nanocarriers at 2?3 mg/mL concentration in isotonic buffers and serum. For 120?170 nm spherical LbL nanocapsules of low soluble anticancer drugs, polyelectrolyte shell thickness controls drug dissolution. As for nanotube carriers, we concentrated on natural halloysite clay nanotubes as cores for LbL encapsulation that allows high drug loading and sustains its release over tens and hundreds hours. Further drug release prolongation was reached with formation of the tube-end stoppers.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	T.G. Shutava, R.F. Fakhrullin, Y.M. Lvov, “Spherical and tubule nanocarriers for sustained drug release” Curr. Opin. Pharmacol., 2014, 18, 141–148.	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU