КФУ. Карточка публикации. Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide

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BACTERIAL ENZYMES EFFECTIVELY DIGEST ALZHEIMER'S β-AMYLOID PEPTIDE

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Балабан Нэлли Павловна, автор

Данилова Юлия Васильевна, автор

Маргулис Анна Борисовна, автор

Рудакова Наталья Леонидовна, автор

Тойменцева Анна Александровна, автор

Шагимарданова Елена Ильясовна, автор

Шарипова Маргарита Рашидовна, автор

Другие авторы

Palotás A.

Библиографическое описание на языке оригинала

Danilova Y.V. Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide / Y.V. Danilova, E.I. Shagimardanova, A.B. Margulis, A.A. Toymentseva, N.P. Balaban, N.L. Rudakova, A.A. Rizvanov, M.R. Sharipova, A. Palotás // Brain Res Bull. - 2014. V.108, No.1. - P.113-117.

Аннотация

Aggregated β-amyloid peptides play key roles in the development of Alzheimer's disease, and recent evidence suggests that microbial particles, among others, can facilitate their polymerization. Bacterial enzymes, however, have been proved to be beneficial in degrading pathological fibrillar structures in clinical settings, such as strepto-kinases in resolving blood-clots. The purpose of this study was to investigate the ability of bacterial substances to effectively hydrolyze β-amyloid peptides. Degrading products of several proteinases from Bacillus pumilus were evaluated using MALDI-TOF mass-spectrometry, and their toxicity was assessed in vitro using cell-culture assays and morphological studies. These enzymes have proved to be non-toxic and were demonstrated to cleave through the functional domains of β-amyloid peptide. By yielding inactive fragments, proteinases of Bacillus pumilus may be used as candidate anti-amyloid agents.

Ключевые слова

Bacillus pumilus, extracellular proteinases, Alzheimer's β-amyloid, MALDI-TOF mass-spectrometry

Название журнала

BRAIN RES BULL

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https://repository.kpfu.ru/?p_id=90036

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Балабан Нэлли Павловна	ru_RU
dc.contributor.author	Данилова Юлия Васильевна	ru_RU
dc.contributor.author	Маргулис Анна Борисовна	ru_RU
dc.contributor.author	Рудакова Наталья Леонидовна	ru_RU
dc.contributor.author	Тойменцева Анна Александровна	ru_RU
dc.contributor.author	Шагимарданова Елена Ильясовна	ru_RU
dc.contributor.author	Шарипова Маргарита Рашидовна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Danilova Y.V. Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide / Y.V. Danilova, E.I. Shagimardanova, A.B. Margulis, A.A. Toymentseva, N.P. Balaban, N.L. Rudakova, A.A. Rizvanov, M.R. Sharipova, A. Palotás // Brain Res Bull. - 2014. V.108, No.1. - P.113-117.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=90036	ru_RU
dc.description.abstract	BRAIN RES BULL	ru_RU
dc.description.abstract	Aggregated β-amyloid peptides play key roles in the development of Alzheimer's disease, and recent evidence suggests that microbial particles, among others, can facilitate their polymerization. Bacterial enzymes, however, have been proved to be beneficial in degrading pathological fibrillar structures in clinical settings, such as strepto-kinases in resolving blood-clots. The purpose of this study was to investigate the ability of bacterial substances to effectively hydrolyze β-amyloid peptides. Degrading products of several proteinases from Bacillus pumilus were evaluated using MALDI-TOF mass-spectrometry, and their toxicity was assessed in vitro using cell-culture assays and morphological studies. These enzymes have proved to be non-toxic and were demonstrated to cleave through the functional domains of β-amyloid peptide. By yielding inactive fragments, proteinases of Bacillus pumilus may be used as candidate anti-amyloid agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bacillus pumilus	ru_RU
dc.subject	extracellular proteinases	ru_RU
dc.subject	Alzheimer's β-amyloid	ru_RU
dc.subject	MALDI-TOF mass-spectrometry	ru_RU
dc.title	Bacterial enzymes effectively digest Alzheimer's β-amyloid peptide	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU