КФУ. Карточка публикации. The ATP binding properties of PII protein GlnK from Bacillus subtilis.

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THE ATP BINDING PROPERTIES OF PII PROTEIN GLNK FROM BACILLUS SUBTILIS.

Форма представления

Тезисы и материалы конференций в зарубежных журналах и сборниках

Год публикации

2012

Авторы, сотрудники КФУ

Каюмов Айрат Рашитович, автор

Другие авторы

K. Forchhammer

Библиографическое описание на языке оригинала

A.R. Kayumov, K. Forchhammer. The ATP binding properties of PII protein GlnK from Bacillus subtilis // Materialen des wissenschaftlichen Seminars von Stipendiaten der Programme "Michail Lomonosov II" und "Immanuel Kant II" 2011/12. Moskau, 28-29 April 2012. - S.63-66.

Аннотация

The PII proteins are presented in almost all bacterial cells. In response lo ATP and 2-oxoglutatrate level in the cell Pll proteins regulates the activity of glutamine synthetase and activates the histidine kinase NtrB, which phosphorilates its cognate response regulator NtrC. The B.subtilis GlnK protein, although exhibiting unique features, was shown to bind to the membrane in an AmtB dependent manner and binds transcription factor TnrA. B.subtilis GlnK was shown to bind only ATP and not 2-oxoglutarate in contrast to other GlnK proteins. The point mutation Gly94 Ala abolishes ATP binding. In vivo, this protein is completely bound to membrane and not in a cytoplasm. This indicates that ATP is an intracellular signal regulating GlnK activity.

Ключевые слова

B.subtilis, GlnK

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https://repository.kpfu.ru/?p_id=90498

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Каюмов Айрат Рашитович	ru_RU
dc.date.accessioned	2012-01-01T00:00:00Z	ru_RU
dc.date.available	2012-01-01T00:00:00Z	ru_RU
dc.date.issued	2012	ru_RU
dc.identifier.citation	A.R. Kayumov, K. Forchhammer. The ATP binding properties of PII protein GlnK from Bacillus subtilis // Materialen des wissenschaftlichen Seminars von Stipendiaten der Programme "Michail Lomonosov II" und "Immanuel Kant II" 2011/12. Moskau, 28-29 April 2012. - S.63-66.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=90498	ru_RU
dc.description.abstract	The PII proteins are presented in almost all bacterial cells. In response lo ATP and 2-oxoglutatrate level in the cell Pll proteins regulates the activity of glutamine synthetase and activates the histidine kinase NtrB, which phosphorilates its cognate response regulator NtrC. The B.subtilis GlnK protein, although exhibiting unique features, was shown to bind to the membrane in an AmtB dependent manner and binds transcription factor TnrA. B.subtilis GlnK was shown to bind only ATP and not 2-oxoglutarate in contrast to other GlnK proteins. The point mutation Gly94 Ala abolishes ATP binding. In vivo, this protein is completely bound to membrane and not in a cytoplasm. This indicates that ATP is an intracellular signal regulating GlnK activity.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	B.subtilis	ru_RU
dc.subject	GlnK	ru_RU
dc.title	The ATP binding properties of PII protein GlnK from Bacillus subtilis.	ru_RU
dc.type	Тезисы и материалы конференций в зарубежных журналах и сборниках	ru_RU