КФУ. Карточка публикации. Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals

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CHEMICAL GLYCAN CONJUGATION CONTROLS THE BIODISTRIBUTION AND KINETICS OF PROTEINS IN LIVE ANIMALS

Форма представления

Статьи в зарубежных журналах и сборниках

Год публикации

2014

Авторы, сотрудники КФУ

Курбангалиева Альмира Рафаэловна, автор

Другие авторы

A. Ogura

Библиографическое описание на языке оригинала

A. Ogura, A. Kurbangalieva, K. Tanaka. Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals // Mini-Rev. Med. Chem. 2014. V. 14. № 13. P. 1072–1077.

Аннотация

The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.

Ключевые слова

Albumin, bioconjugation, biodistribution, chemical reaction, in vivo imaging, neoglycoprotein, N-glycans, tumor targeting.

Название журнала

MINI-REV MEDCHEM

URL

http://benthamscience.com/journal/abstracts.php?journalID=mrmc&articleID=126443

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https://repository.kpfu.ru/?p_id=94721

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Курбангалиева Альмира Рафаэловна	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	A. Ogura, A. Kurbangalieva, K. Tanaka. Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals // Mini-Rev. Med. Chem. 2014. V. 14. № 13. P. 1072–1077.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=94721	ru_RU
dc.description.abstract	MINI-REV MEDCHEM	ru_RU
dc.description.abstract	The biodistributions and in vivo kinetics of chemically prepared neoglycoproteins have been examined previously and are reviewed here. A variety of mono- and oligosaccharides may be conjugated onto a protein surface using chemical methods. The kinetics and organ-specific accumulation profiles of these glycoconjugates, introduced through intravenous injection, have been analyzed using conventional dissection studies as well as noninvasive methods, such as SPECT, PET, or fluorescence imaging. These studies have revealed glycan-dependent protein distribution kinetics that may be useful for pharmacological and diagnostic applications.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Albumin	ru_RU
dc.subject	bioconjugation	ru_RU
dc.subject	biodistribution	ru_RU
dc.subject	chemical reaction	ru_RU
dc.subject	in vivo imaging	ru_RU
dc.subject	neoglycoprotein	ru_RU
dc.subject	N-glycans	ru_RU
dc.subject	tumor targeting.	ru_RU
dc.title	Chemical Glycan Conjugation Controls the Biodistribution and Kinetics of Proteins in Live Animals	ru_RU
dc.type	Статьи в зарубежных журналах и сборниках	ru_RU