| Форма представления | Статьи в зарубежных журналах и сборниках |
| Год публикации | 2014 |
|
Курбангалиева Альмира Рафаэловна, автор
|
| Другие авторы |
M. Takamatsu; K. Fukase |
| Библиографическое описание на языке оригинала |
M. Takamatsu, K. Fukase, A. Kurbangalieva, K. Tanaka. Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker // Bioorg. Med. Chem. 2014. V. 22. № 22. P. 6380–6386. |
| Аннотация |
We demonstrated synthetically that the eight-membered heterocycles 2,6,9-triazabicyclo[3.3.1]nonanes and 1,5-diazacyclooctanes are the initial and exclusive products of the reaction, through an imino [4+4] cycloaddition, of biologically relevant amines with acrolein. The stabilities of the aminoacetals within the eight-membered heterocycles determined whether the product was subsequently transformed gradually into the 3-formyl-3,4-dehydropiperidine (FDP), which is widely used as an oxidative stress marker. The reactivity profiles discovered in this study suggested that some of the imino [4+4] cycloaddition products are reactive intermediates of FDP and contribute to the mechanisms underlying the oxidative stress response to acrolein. |
| Ключевые слова |
Acrolein, Biologically relevant amine, Biomarker, 1,5-Diazacyclooctane, 3-Formyl-3,4-dehydropiperidine (FDP), Imino [4+4] cycloaddition, 2,6,9-Triazabicyclo[3.3.1]nonane |
| Название журнала |
Bioorganic & Medicinal Chemistry
|
| URL |
http://www.sciencedirect.com/science/article/pii/S0968089614006993 |
| Пожалуйста, используйте этот идентификатор, чтобы цитировать или ссылаться на эту карточку |
https://repository.kpfu.ru/?p_id=94723 |
Полная запись метаданных  |
| Поле DC |
Значение |
Язык |
| dc.contributor.author |
Курбангалиева Альмира Рафаэловна |
ru_RU |
| dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2014 |
ru_RU |
| dc.identifier.citation |
M. Takamatsu, K. Fukase, A. Kurbangalieva, K. Tanaka. Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker // Bioorg. Med. Chem. 2014. V. 22. № 22. P. 6380–6386. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/?p_id=94723 |
ru_RU |
| dc.description.abstract |
Bioorganic & Medicinal Chemistry |
ru_RU |
| dc.description.abstract |
We demonstrated synthetically that the eight-membered heterocycles 2,6,9-triazabicyclo[3.3.1]nonanes and 1,5-diazacyclooctanes are the initial and exclusive products of the reaction, through an imino [4+4] cycloaddition, of biologically relevant amines with acrolein. The stabilities of the aminoacetals within the eight-membered heterocycles determined whether the product was subsequently transformed gradually into the 3-formyl-3,4-dehydropiperidine (FDP), which is widely used as an oxidative stress marker. The reactivity profiles discovered in this study suggested that some of the imino [4+4] cycloaddition products are reactive intermediates of FDP and contribute to the mechanisms underlying the oxidative stress response to acrolein. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
Acrolein |
ru_RU |
| dc.subject |
Biologically relevant amine |
ru_RU |
| dc.subject |
Biomarker |
ru_RU |
| dc.subject |
1 |
ru_RU |
| dc.subject |
5-Diazacyclooctane |
ru_RU |
| dc.subject |
3-Formyl-3 |
ru_RU |
| dc.subject |
4-dehydropiperidine (FDP) |
ru_RU |
| dc.subject |
Imino [4+4] cycloaddition |
ru_RU |
| dc.subject |
2 |
ru_RU |
| dc.subject |
6 |
ru_RU |
| dc.subject |
9-Triazabicyclo[3.3.1]nonane |
ru_RU |
| dc.title |
Imino [4+4] cycloaddition products as exclusive and biologically relevant acrolein-amine conjugates are intermediates of 3-formyl-3,4-dehydropiperidine (FDP), an acrolein biomarker |
ru_RU |
| dc.type |
Статьи в зарубежных журналах и сборниках |
ru_RU |
|
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