КФУ. Карточка публикации. Ribonucleases as antiviral agents

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RIBONUCLEASES AS ANTIVIRAL AGENTS

Форма представления

Статьи в российских журналах и сборниках

Год публикации

2014

Язык

русский

Авторы, сотрудники КФУ

Ильинская Ольга Николаевна, автор

Шах Махмуд Раихан , автор

Библиографическое описание на языке оригинала

Ilinskaya O. N. Ribonucleases as antiviral agents / O. N. Ilinskaya, R. Shah Mahmud// Molecular biology. - 2014. - V. 48, I. 5. - P. 615-623.

Аннотация

Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review dis- cusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and eosinophil-associated RNases) and exogenous RNases (RNase A, BS-RNase, onconase, binase, and synthetic RNases). Attention is paid to two important, but not always obligatory, aspects of molecules of RNases that have antiviral properties, i.e., catalytic activity and ability to dimerize. The hypo- thetic scheme of virus elimination by exogenous RNases that reflects possible types of interaction of viruses and RNases with a cell is proposed. The evidence for RNases as classical components of immune defense and thus perspective agents for the development of new antiviral therapeutics is proposed.

Ключевые слова

viruses, antiviral activity, RNase L, MCPIP1 protein, eosinophil-associated RNases, RNase A, BS-RNase, onconase, binase, synthetic RNase

Название журнала

Молекулярная биология

URL

http://link.springer.com/article/10.1134%2FS0026893314040050

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https://repository.kpfu.ru/?p_id=95713

Полная запись метаданных

Поле DC	Значение	Язык
dc.contributor.author	Ильинская Ольга Николаевна	ru_RU
dc.contributor.author	Шах Махмуд Раихан	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Ilinskaya O. N. Ribonucleases as antiviral agents / O. N. Ilinskaya, R. Shah Mahmud// Molecular biology. - 2014. - V. 48, I. 5. - P. 615-623.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/?p_id=95713	ru_RU
dc.description.abstract	Молекулярная биология	ru_RU
dc.description.abstract	Many ribonucleases (RNases) are able to inhibit the reproduction of viruses in infected cell cultures and laboratory animals, but the molecular mechanisms of their antiviral activity remain unclear. The review dis- cusses the well-known RNases that possess established antiviral effects, including both intracellular RNases (RNase L, MCPIP1 protein, and eosinophil-associated RNases) and exogenous RNases (RNase A, BS-RNase, onconase, binase, and synthetic RNases). Attention is paid to two important, but not always obligatory, aspects of molecules of RNases that have antiviral properties, i.e., catalytic activity and ability to dimerize. The hypo- thetic scheme of virus elimination by exogenous RNases that reflects possible types of interaction of viruses and RNases with a cell is proposed. The evidence for RNases as classical components of immune defense and thus perspective agents for the development of new antiviral therapeutics is proposed.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	viruses	ru_RU
dc.subject	antiviral activity	ru_RU
dc.subject	RNase L	ru_RU
dc.subject	MCPIP1 protein	ru_RU
dc.subject	eosinophil-associated RNases	ru_RU
dc.subject	RNase A	ru_RU
dc.subject	BS-RNase	ru_RU
dc.subject	onconase	ru_RU
dc.subject	binase	ru_RU
dc.subject	synthetic RNase	ru_RU
dc.title	Ribonucleases as antiviral agents	ru_RU
dc.type	Статьи в российских журналах и сборниках	ru_RU