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KFU's catalog of scientific and educational resources:
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....Institute of Ecology and Geography
....Institute of Geology and Petroleum Technologies
....Institute of Physics
....Alexander Butlerov Institute of Chemistry
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A new formulation of methylprednisolone succinate (MPS) with pre-oxidized carboxylated trifunctional block copolymer of ethylene oxide (EO) and propylene oxide (PO) (TBC?COOH) has been developed. TBC?COOH aggregates are spontaneously rearranged by MPS producing highly homogeneous mixed micelles (TBC?COOH/MPS) with hydrodynamic diameter of 19.6?0.3 nm, zeta potential of ?27.8?3.2 mV (pH 7.0) and with optimal weight ratio 1:6.3. The role of polypropylene oxide component in a copolymer and methylprednisolone succinylation in forming the mixed micelles was studied by comparing copolymers and corticosteroids of different structure. Micellar structure TBC?COOH/MPS is highly resistant to a dilution, temperature fluctuations and the presence of blood serum components. TBC?COOH promotes intrinsic cytotoxicity of increased concentrations of MPS for SH-SY5Y and PC-12 cells after 7-hour exposure attributed to enhanced cellular availability of the mixed micelles
2018
Abdullin Timur Ildarovich
Dang Tkhi Vet Chin
Akhmedov, A.A. Supramolecular Amphiphiles Based on Pillar[5]arene and Meroterpenoids: Synthesis, Self-Association and Interaction with Floxuridine / A.A. Akhmedov, D.N. Shurpik, P.L. Padnya, A.I. Khadieva, R.R. Gamirov, Y.V. Panina, A.F. Gazizova, D.Y. Grishaev, V.V. Plemenkov, I.I. Stoikov // Int. J. Mol. Sci. ? 2021. ? V. 22. ? № 15. ? Reg. 7950. doi:10.3390/ijms22157950
2021
Gazizova Asiya Fanilovna
Grishaev Denis Yurevich
Padnya Pavel Leonidovich
Plemenkov Vitaliy Vladimirovich
Stoykov Ivan Ivanovich
Khadieva Alyona Igorevna
Shurpik Dmitriy Nikolaevich
Gamirov Rustem Rinatovich
Panina Yuliya Vladislavovna
Synthesis and characterization of pyridoxine, nicotine and nicotinamide salts of dithiophosphoric acids as antibacterial agents against resistant wound infection
2018
Abdullin Timur Ildarovich
Dang Tkhi Vet Chin
This work presents the results of in-vitro biological activity studies of three novel anticancer agents, phosphonium salts based on the 3-hydroxypyridine scaffold, including one derivative of 4-deoxypyridoxine. Proliferation and viability of cells treated with these compounds was assessed by the colony formation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Effects of the compounds on apoptosis and cell cycle were studied by flow cytometry using annexin V-FITC/propidium iodide and propidium iodide staining, respectively. The influence of the compounds on mitochondrial membrane potential and intracellular reactive oxygen species was evaluated using tetramethyl rhodamine ethyl and DCFHA staining. Western blot analysis was used to study the changes in the expression of Bcl-xL, Bax, and caspase-3 apoptotic proteins. The treatment of ovarian adenocarcinoma cells OVCAR-4 with the tested compounds inhibited the growth and induced cell cycle arrest in the G1 phase. 3
2018
Akhunzyanov Almaz Anasovich
Gabbasova Railya Raushanovna
Iksanova Alfiya Gabdulakhatovna
Kupriyanova Tatyana Viktorovna
Zakirova E. Handbook of Stem Cell Therapy / E. Zakirova, A. M. Aimaletdinov, A. G. Malanyeva, С. S. Rutland, and A. A. Rizvanov; K. H. Haider (ed.). - Springer Nature Singapore Pte Ltd, 2022.
2022
Aymaletdinov Aleksandr Maazovich
Zakirova Elena Yurevna
Malaneva Albina Gennadevna
Rizvanov Albert Anatolevich
К.В. Балакин, Ю.Г. Штырлин. Медицинская химия. Иллюстрации к современным технологиям разработки лекарств – LAP LAMBERT Academic Publishing RU, ISBN 978-3-659-94956-2, 2017. – 256 с.
2017
Balakin Konstantin Valerevich
Shtyrlin Yuriy Grigorevich
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