KFU. Card publication. Age-dependent peculiarities of the rat's heart cholinergic regulation

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AGE-DEPENDENT PECULIARITIES OF THE RAT'S HEART CHOLINERGIC REGULATION

Form of presentation

Articles in Russian journals and collections

Year of publication

2015

Язык

русский

Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Khabibrakhmanov Insaf Ilkhamovich, author

Other authors

Zefirov Andrey Lvovich, author

Bibliographic description in the original language

Zefirov T.L. Age-dependent peculiarities of the rat's heart cholinergic regulation / T.L. Zefirov, N.I. Ziatdinova, I.I. Khabibrakhmanov // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. Volume 101, Issue 2, 1 February 2015, Pages 189-199.

Annotation

In vitro and in vivo studies were performed to investigate the effects of M1-, M2-, M3-cholinoreceptors (M-AChR) blockade on the chronotropic and inotropic cardiac function in the rats of 1, 3, 6, 8 and 20 weeks old. These age groups were selected according to the development level of the autonomic regulation of the heart. It was found that the prior blockade of all three subtypes M-AChR did not prevent inhibitory effect of carbacholin on contractility of the atria and ventricles the animals of all studied age groups. The presence of the positive chronotropic response was found after blockade of M3-cholinoreceptor in 20 weeks-old rats. The absence of cardiac chronotropic response to the blockade of M2-receptor was revealed. In 3, 6, 8 weeks-old rats the selective blockade of M-AChR does not change of the heart chronotrope. At the same time, the effect of the M1- and M2-AChR blockade on myocardial contractility was revealed.

Keywords

Rat, muscarinic cholinoreceptors, heart

The name of the journal

Neuroscience and Behavioral Physiology

URL

https://www.scopus.com/record/display.uri?eid=2-s2.0-84930692171&origin=resultslist&sort=plf-f&src=s&sid=4B8F82B73D39BAD3414E8C2ECB36FCB2.wsnAw8kcdt7IPYLO0V48gA%3a360&sot=autdocs&sdt=autdocs&sl=18&s=AU-ID%2856561820400%29&relpos=1&citeCnt=0&searchTerm=

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=100046&p_lang=2

Resource files

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RFZh__2.pdf	0,12	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Khabibrakhmanov Insaf Ilkhamovich	ru_RU
dc.contributor.author	Zefirov Andrey Lvovich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Zefirov T.L. Age-dependent peculiarities of the rat's heart cholinergic regulation / T.L. Zefirov, N.I. Ziatdinova, I.I. Khabibrakhmanov // Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk. Volume 101, Issue 2, 1 February 2015, Pages 189-199.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=100046&p_lang=2	ru_RU
dc.description.abstract	Neuroscience and Behavioral Physiology	ru_RU
dc.description.abstract	In vitro and in vivo studies were performed to investigate the effects of M1-, M2-, M3-cholinoreceptors (M-AChR) blockade on the chronotropic and inotropic cardiac function in the rats of 1, 3, 6, 8 and 20 weeks old. These age groups were selected according to the development level of the autonomic regulation of the heart. It was found that the prior blockade of all three subtypes M-AChR did not prevent inhibitory effect of carbacholin on contractility of the atria and ventricles the animals of all studied age groups. The presence of the positive chronotropic response was found after blockade of M3-cholinoreceptor in 20 weeks-old rats. The absence of cardiac chronotropic response to the blockade of M2-receptor was revealed. In 3, 6, 8 weeks-old rats the selective blockade of M-AChR does not change of the heart chronotrope. At the same time, the effect of the M1- and M2-AChR blockade on myocardial contractility was revealed.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Rat	ru_RU
dc.subject	muscarinic cholinoreceptors	ru_RU
dc.subject	heart	ru_RU
dc.title	Age-dependent peculiarities of the rat's heart cholinergic regulation	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU