KFU. Card publication. Investigation of DNA binding abilities of solid lipid nanoparticles based on p-tert-butylthiacalix[4]- arene platform

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FEDERAL UNIVERSITY

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INVESTIGATION OF DNA BINDING ABILITIES OF SOLID LIPID NANOPARTICLES BASED ON P-TERT-BUTYLTHIACALIX[4]- ARENE PLATFORM

Form of presentation

Articles in Russian journals and collections

Year of publication

2015

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Authors, employees of KFU

Galukhin Andrey Vladimirovich, author

Erokhin Anton Alekseevich, author

Osin Yuriy Nikolaevich, author

Bibliographic description in the original language

Andrey Galukhin, Anton Erokhin, Ilnaz Imatdinov and Yuri Osin Investigation of DNA binding abilities of solid lipid nanoparticles based on p-tert-butylthiacalix[4]- arene platform // RSC Advances The Royal Society of Chemistry 2015 pp.33351-33355

Annotation

This journal is ? The Royal Society of Chemistry

Keywords

DNA binding, solid lipid nanoparticles,p-tert-butylthiacalix[4]- arene platform

The name of the journal

This journal is ? The Royal Society of Chemistry

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=106147&p_lang=2

Resource files

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Article.Galuhin.pdf	1,19	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Galukhin Andrey Vladimirovich	ru_RU
dc.contributor.author	Erokhin Anton Alekseevich	ru_RU
dc.contributor.author	Osin Yuriy Nikolaevich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Andrey Galukhin, Anton Erokhin, Ilnaz Imatdinov and Yuri Osin Investigation of DNA binding abilities of solid lipid nanoparticles based on p-tert-butylthiacalix[4]- arene platform // RSC Advances The Royal Society of Chemistry 2015 pp.33351-33355	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=106147&p_lang=2	ru_RU
dc.description.abstract	This journal is ? The Royal Society of Chemistry	ru_RU
dc.description.abstract	An amphiphilic thiacalix[4]arene derivative functionalized with guanidinium groups forms stable solid lipid nanoparticles (SLNs) with high z-potential in water. Applying gel electrophoresis and fluorescent spectroscopy methods shows that the SLNs have high binding affinity to double-stranded DNA, but despite this fact, we have not observed any significant transfection activity toward three different mammalian cell lines. A UV-spectroscopic study reveals that interaction between the SLNs and the polynucleotide leads to partial denaturation of the DNA located on the surface of the nanoparticles that can hinder transfection.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	DNA binding	ru_RU
dc.subject	solid lipid nanoparticles	ru_RU
dc.subject	p-tert-butylthiacalix[4]- arene platform	ru_RU
dc.title	Investigation of DNA binding abilities of solid lipid nanoparticles based on p-tert-butylthiacalix[4]- arene platform	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU