KFU. Card publication. Generation and Validation of miR-142 Knock Out Mice

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

GENERATION AND VALIDATION OF MIR-142 KNOCK OUT MICE

Form of presentation

Articles in international journals and collections

Year of publication

2015

Язык

английский

Authors, employees of KFU

Beluchi Saverio , author

Mukhametshina Regina Talgatovna, author

Bibliographic description in the original language

Shrestha A. Generation and Validation of miR-142 Knock Out Mice / Shrestha A., Carraro G., El Agha E., Mukhametshina R., Chao C.M., Rizvanov A.A., Barreto G., Bellusci S. // PLoS One. – 2015. – Vol.10(9). e0136913. - DOI: 10.1371/journal.pone.0136913.

Annotation

microRNA-142 (miR-142) is an important regulator of many biological processes and associated signaling pathways during embryonic development, homeostasis and disease. The miR-142 hairpin gives rise to the ?guide strand? miR-142-3p and the sister "passenger" strand miR-142-5p. miR-142-3p has been shown to play critical, non-redundant functions in the development of the hematopoietic lineage. We have recently reported that miR-142-3p is critical for the control of Wnt signaling in the mesenchyme of the developing lung. miR-142-5p has been proposed to control adaptive growth in cardiomyocytes postnatally and its increase is associated with extensive apoptosis and cardiac dysfunction in a murine heart failure model. Using homologous recombination, we now report the generation and validation of miR-142-null mice. miR-142-null mice show a significant decrease in th expression levels of both the 3p and 5p isoforms.

Keywords

Knock Out Mice

The name of the journal

PLos ONE

URL

http://www.ncbi.nlm.nih.gov/pubmed/26327117

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=113225&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Beluchi Saverio	ru_RU
dc.contributor.author	Mukhametshina Regina Talgatovna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Shrestha A. Generation and Validation of miR-142 Knock Out Mice / Shrestha A., Carraro G., El Agha E., Mukhametshina R., Chao C.M., Rizvanov A.A., Barreto G., Bellusci S. // PLoS One. – 2015. – Vol.10(9). e0136913. - DOI: 10.1371/journal.pone.0136913.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=113225&p_lang=2	ru_RU
dc.description.abstract	PLos ONE	ru_RU
dc.description.abstract	microRNA-142 (miR-142) is an important regulator of many biological processes and associated signaling pathways during embryonic development, homeostasis and disease. The miR-142 hairpin gives rise to the ?guide strand? miR-142-3p and the sister "passenger" strand miR-142-5p. miR-142-3p has been shown to play critical, non-redundant functions in the development of the hematopoietic lineage. We have recently reported that miR-142-3p is critical for the control of Wnt signaling in the mesenchyme of the developing lung. miR-142-5p has been proposed to control adaptive growth in cardiomyocytes postnatally and its increase is associated with extensive apoptosis and cardiac dysfunction in a murine heart failure model. Using homologous recombination, we now report the generation and validation of miR-142-null mice. miR-142-null mice show a significant decrease in th expression levels of both the 3p and 5p isoforms.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Generation and Validation of miR-142 Knock Out Mice	ru_RU
dc.type	Articles in international journals and collections	ru_RU