Form of presentation | Articles in Russian journals and collections |
Year of publication | 2014 |
Язык | английский |
|
Sabirullina Guliya Ilnatovna, author
Sitdikova Guzel Faritovna, author
Shafigullin Marat Ulfatovich, author
|
|
Zefirov Andrey Lvovich, author
Zefirov Ruslan Andreevich, author
|
|
Sabirullina Guliya Ilnatovna, postgraduate kfu
|
Bibliographic description in the original language |
M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov, G. F. Sitdikova. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum. Bulletin of Experimental Biology and Medicine/ Russian Academy of Medical Sciences/ - t.157. - №3 - 302-306. |
Annotation |
We studied the effect of sodium hydrosulfi te (NaHS), a donor of hydrogen sulfi de (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specifi c antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum
by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels. |
Keywords |
hydrogen sulfi de; smooth muscle cells; stomach; jejunum; potassium channels |
The name of the journal |
Bulletin of Experimental Biology and Medicine
|
Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=120336&p_lang=2 |
Resource files | |
|
Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Sabirullina Guliya Ilnatovna |
ru_RU |
dc.contributor.author |
Sitdikova Guzel Faritovna |
ru_RU |
dc.contributor.author |
Shafigullin Marat Ulfatovich |
ru_RU |
dc.contributor.author |
Zefirov Andrey Lvovich |
ru_RU |
dc.contributor.author |
Zefirov Ruslan Andreevich |
ru_RU |
dc.contributor.author |
Sabirullina Guliya Ilnatovna |
ru_RU |
dc.date.accessioned |
2014-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2014-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2014 |
ru_RU |
dc.identifier.citation |
M. Y. Shafigullin, R. A. Zefirov, G. I. Sabirullina, A. L. Zefirov, G. F. Sitdikova. Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum. Bulletin of Experimental Biology and Medicine/ Russian Academy of Medical Sciences/ - т.157. - №3 - 302-306. |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=120336&p_lang=2 |
ru_RU |
dc.description.abstract |
Bulletin of Experimental Biology and Medicine |
ru_RU |
dc.description.abstract |
We studied the effect of sodium hydrosulfi te (NaHS), a donor of hydrogen sulfi de (H2S), on spontaneous contractive activity of isolated preparations of rat stomach and jejunum under isometric conditions. NaHS in concentrations of 10-200 μM reduced the amplitude, tonic tension, and frequency of contractions of the preparations. Blockade of K+ channels with a non-specifi c antagonist tetraethylammonium (10 mM) increased contraction amplitude in the stomach strip and jejunum segment. The effects of NaHS on all parameters of contractile activity of the stomach and jejunum were fully preserved against the background of tetraethylammonium application. These data suggest that H2S in physiologically relevant concentrations inhibited spontaneous contractile activity of smooth muscle cells in rat stomach and jejunum
by reducing the amplitude and frequency of contractions and decreased tonic tension without affecting the function of voltage- and calcium-dependent K+ channels. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
|
ru_RU |
dc.title |
Effects of a Hydrogen Sulfide Donor on Spontaneous Contractile Activity of Rat Stomach and Jejunum |
ru_RU |
dc.type |
Articles in Russian journals and collections |
ru_RU |
|