Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
КАМАЛОВ, М. И. НЕИНВАЗИВНАЯ АКТУАЛЬНЫМ ДОСТАВКИ ЛЕКАРСТВ К СПИННОМУ МОЗГУ С КАРБОКСИЛЬНОЙ МОДИФИЦИРОВАННЫЙ ТРИФУНКЦИОНАЛЬНОГО СОПОЛИМЕРА ОКИСИ ЭТИЛЕНА И ОКИСИ ПРОПИЛЕНА / MI КАМАЛОВ, И.А. ЛАВРОВ, А. А. YERGESHOV, З.Ы. СИРАЕВА, ME БАЛТИН, А.А. РИЗВАНОВ, С.В. КУЗНЕЦОВА, Н. В. ПЕТРОВА, И.Н. САВИНА, Т. АБДУЛЛИН // КОЛЛОИДОВ И ПОВЕРХНОСТЕЙ B: BIOINTERFACES. - 2016. - V. 140, № 1. - С. 196-203
Form of presentationArticles in international journals and collections
Year of publication2016
Языкрусский
  • Abdullin Timur Ildarovich, author
  • Baltin Maksim Eduardovich, author
  • Lavrov Igor Aleksandrovich, author
  • Petrova Natalya Valentinovna, author
  • Rizvanov Albert Anatolevich, author
  • Siraeva Zulfira Yunysovna, author
  • Baltin Maksim Eduardovich, postgraduate kfu
  • Ergeshov Abdulla Arslanovich, postgraduate kfu
  • Bibliographic description in the original language Marat Kamalov; Igor Lavrov, Ph.D.; Abdulla Ergeshov; Zulfira Siraeva, Ph.D.; Maxim Baltin; Albert Rizvanov, Ph.D.; Svetlana Kuznetcova; Natalia Petrova, Ph.D.; Irina Savina, Ph.D., Non-invasive topical drug delivery to spinal cord with carboxyl-modified trifunctional copolymer of ethylene oxide and propylene oxide//Colloids and Surfaces B: Biointerfaces.- 2016. - V. 140, № 1. - S. 196-203
    Annotation In this study the effect of oxidative modification on micellar and drug delivery properties of copolymers of ethylene oxide (EO) and propylene oxide (PO) was investigated. Carboxylated trifunctional copolymers were synthesized in the reaction with chromium(VI) oxide. We found that carboxylation significantly improved the uniformity and stability of polymeric micelles by inhibiting the microphase transition. The cytotoxicity of copolymers was studied in relation to their aggregative state on two cell types (cancer line vs. primary fibroblasts). The accumulation of rhodamine 123 in neuroblastoma SH-SY5Y cells was dramatically increased in the presence of the oxidized block copolymer with the number of PO and EO units of 83.5 and 24.2, respectively. The copolymer was also tested as an enhancer for topical drug delivery to the spinal cord when applied subdurally. The oxidized copolymer facilitated the penetration of rhodamine 123 across spinal cord tissues and increased its intraspinal acc
    Keywords Амфифильные полимеры ;Трифункциональные сополимеры этиленоксида и пропиленоксида ;Окислительная модификация ;мицеллы ;Доставка лекарств ;Нервные клетки ;Спинной мозг ;Травматическое повреждение
    The name of the journal Colloids and Surfaces B: Biointerfaces
    URL http://www.sciencedirect.com/science/article/pii/S0927776515303842
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=127339&p_lang=2

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