KFU. Card publication. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells

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UNCATALYZED CLICK REACTION BETWEEN PHENYL AZIDES AND ACROLEIN: 4-FORMYL-1,2,3-TRIAZOLINES AS &LDQUO;CLICKED&RDQUO; MARKERS FOR VISUALIZATIONS OF EXTRACELLULAR ACROLEIN RELEASED FROM OXIDATIVELY STRESSED CELLS

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Saygitbatalova Elena Shiripovna, author

Authors, postgraduates KFU

Saygitbatalova Elena Shiripovna, postgraduate kfu

Bibliographic description in the original language

Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. - 2016. - V. 1. - � 5. - P. 623-632.

Annotation

Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a ?click? manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.

Keywords

acrolein, aryl azide, oxidative stress, cell imaging, click chemistry

The name of the journal

ACS Sensors

URL

http://pubs.acs.org/doi/abs/10.1021/acssensors.6b00122

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=128200&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Pradipta A. R. Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells / A. R. Pradipta, M. Taichi, I. Nakase, E. Saigitbatalova, A. Kurbangalieva, S. Kitazume, N. Taniguchi, K. Tanaka // ACS Sens. - 2016. - V. 1. - � 5. - P. 623-632.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=128200&p_lang=2	ru_RU
dc.description.abstract	ACS Sensors	ru_RU
dc.description.abstract	Acrolein, a highly toxic α,β-unsaturated aldehyde, has been a longstanding key biomarker associated with a range of disorders related to oxidative stresses. Currently available analytical methods rely on the indirect protocols, e.g., derivatization/HPLC or mAb detection of the lysine adducts. Consequently, developing new analytical tools for acrolein detection that are straightforward, cost-effective, selective, and preferably feasible using live cells remains a highly essential pursuit in the diagnosis and therapeutic treatment of oxidative stress-related diseases. We demonstrated that for the first time aryl azides can rapidly and selectively react with acrolein in a ?click? manner to provide 4-formyl-1,2,3-triazolines and 4-formyl-1,2,3-triazoles, which represents an unexplored reactivity of aryl azides.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acrolein	ru_RU
dc.subject	aryl azide	ru_RU
dc.subject	oxidative stress	ru_RU
dc.subject	cell imaging	ru_RU
dc.subject	click chemistry	ru_RU
dc.title	Uncatalyzed click reaction between phenyl azides and acrolein: 4-formyl-1,2,3-triazolines as “clicked” markers for visualizations of extracellular acrolein released from oxidatively stressed cells	ru_RU
dc.type	Articles in international journals and collections	ru_RU