KFU. Card publication. Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow.

- RUS
- 中文
- ES

CYCLIN A1 AND P450 AROMATASE PROMOTE METASTATIC HOMING AND GROWTH OF STEM-LIKE PROSTATE CANCER CELLS IN THE BONE MARROW.

Form of presentation

Articles in Russian journals and collections

Year of publication

2016

��

��

Authors, employees of KFU

Miftakhova Regina Rifkatovna, author

Bibliographic description in the original language

Regina Miftakhova, Andreas Hedblom, Julius Semenas, Brian D Robinson, Athanasios Simoulis, Johan Malm, Albert Rizvanov, David David Heery, Nigel P Mongan, Norman J Maitland, Cinzia Allegrucci, Jenny L Persson: Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. Cancer Research, February 2016.

Annotation

Cancer Research

Keywords

Cancer stem cells, Cyclin A1, Aromatase, cancer m

The name of the journal

Cancer Research

URL

http://www.ncbi.nlm.nih.gov/pubmed/26921336

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=130954&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Miftakhova Regina Rifkatovna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Regina Miftakhova, Andreas Hedblom, Julius Semenas, Brian D Robinson, Athanasios Simoulis, Johan Malm, Albert Rizvanov, David David Heery, Nigel P Mongan, Norman J Maitland, Cinzia Allegrucci, Jenny L Persson: Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow. Cancer Research, February 2016.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=130954&p_lang=2	ru_RU
dc.description.abstract	Cancer Research	ru_RU
dc.description.abstract	Bone metastasis is a leading cause of morbidity and mortality in prostate cancer (PCa). While cancer stem-like cells have been implicated as a cell of origin for PCa metastases, the pathways which enable metastatic development at distal sites remain largely unknown. In this study, we illuminate pathways relevant to bone metastasis in this disease. We observed that cyclin A1 (CCNA1) protein expression was relatively higher in PCa metastatic lesions in lymph node, lung, and bone/bone marrow. In both primary and metastatic tissues, cyclin A1 expression was also correlated with aromatase (CYP19A1), a key enzyme that directly regulates the local balance of androgens to estrogens. Cyclin A1 overexpression in the stem-like ALDHhigh subpopulation of PC3M cells, one model of PCa, enabled bone marrow integration and metastatic growth. Further, cells obtained from bone marrow metastatic lesions displayed self-renewal capability in colony forming assays. In the bone marrow, Cyclin A1 and aromatase	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Cancer stem cells	ru_RU
dc.subject	Cyclin A1	ru_RU
dc.subject	Aromatase	ru_RU
dc.subject	cancer m	ru_RU
dc.title	Cyclin A1 and P450 aromatase promote metastatic homing and growth of stem-like prostate cancer cells in the bone marrow.	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU