KFU. Card publication. Impedimetric nanostructured disposable DNA-based biosensors for the detection of deep DNA damage and effect of antioxidants

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IMPEDIMETRIC NANOSTRUCTURED DISPOSABLE DNA-BASED BIOSENSORS FOR THE DETECTION OF DEEP DNA DAMAGE AND EFFECT OF ANTIOXIDANTS

Form of presentation

Articles in international journals and collections

Year of publication

2008

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Authors, employees of KFU

Ziyatdinova Guzel Kamilevna, author

Other authors

Galandova Julia , author

Labuda Jan , author

Bibliographic description in the original language

Ziyatdinova, G. Impedimetric nanostructured disposable DNA-based biosensors for the detection of deep DNA damage and effect of antioxidants / G. Ziyatdinova, J. Galandova, J. Labuda // Intern. J. Electrochem. Sci. - 2008. - V. 3. - No. 3. - P. 223-235.

Annotation

Novel impedimetric nanostructured disposable DNA-biosensors have been created using a layer of multiwalled carbon nanotubes (MWNT) and double stranded calf thymus or herring sperm DNA deposited on the surface of a screen-printed carbon electrode (SPCE) by layer-by-layer and mixed coverage. The presence of DNA significantly decreases the electroconductivity of the MWNT/SPCE interface and represents a charge barrier for the transport of the [Fe(CN6)]3- redox probe ions. Hence, electrochemical impedimetric procedure performed with DNA/MWNT/SPCE sensor in 0.1 M phosphate buffer solution (PBS) pH 7.0 using 1 mM [Fe(CN6)]3- was developed for the evaluation of deep DNA damage caused by reactive oxygen species formed in situ as well as antioxidative effects of rutin and tea extracts.

Keywords

Electrochemical impedance spectroscopy, multiwalled carbon nanotubes, DNA electrochemical biosensor, DNA damage, antioxidants

The name of the journal

International Journal of Electrochemical Science

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866930302&partnerID=40&md5=26c37b25f4f7f7fa506078a5d679d9ee

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=134868&p_lang=2

Resource files

File name	Size (MB)	Format
Impedimetric_Nanostructured_Disposable_DNA_based_Biosensors.pdf	0,19	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziyatdinova Guzel Kamilevna	ru_RU
dc.contributor.author	Galandova Julia	ru_RU
dc.contributor.author	Labuda Jan	ru_RU
dc.date.accessioned	2008-01-01T00:00:00Z	ru_RU
dc.date.available	2008-01-01T00:00:00Z	ru_RU
dc.date.issued	2008	ru_RU
dc.identifier.citation	Ziyatdinova, G. Impedimetric nanostructured disposable DNA-based biosensors for the detection of deep DNA damage and effect of antioxidants / G. Ziyatdinova, J. Galandova, J. Labuda // Intern. J. Electrochem. Sci. - 2008. - V. 3. - No. 3. - P. 223-235.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=134868&p_lang=2	ru_RU
dc.description.abstract	International Journal of Electrochemical Science	ru_RU
dc.description.abstract	Novel impedimetric nanostructured disposable DNA-biosensors have been created using a layer of multiwalled carbon nanotubes (MWNT) and double stranded calf thymus or herring sperm DNA deposited on the surface of a screen-printed carbon electrode (SPCE) by layer-by-layer and mixed coverage. The presence of DNA significantly decreases the electroconductivity of the MWNT/SPCE interface and represents a charge barrier for the transport of the [Fe(CN6)]3- redox probe ions. Hence, electrochemical impedimetric procedure performed with DNA/MWNT/SPCE sensor in 0.1 M phosphate buffer solution (PBS) pH 7.0 using 1 mM [Fe(CN6)]3- was developed for the evaluation of deep DNA damage caused by reactive oxygen species formed in situ as well as antioxidative effects of rutin and tea extracts.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Electrochemical impedance spectroscopy	ru_RU
dc.subject	multiwalled carbon nanotubes	ru_RU
dc.subject	DNA electrochemical biosensor	ru_RU
dc.subject	DNA damage	ru_RU
dc.subject	antioxidants	ru_RU
dc.title	Impedimetric nanostructured disposable DNA-based biosensors for the detection of deep DNA damage and effect of antioxidants	ru_RU
dc.type	Articles in international journals and collections	ru_RU