KFU. Card publication. In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice

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IN VIVO IMAGING OF ADVANCED GLYCATION END PRODUCTS (AGES) OF ALBUMIN: FIRST OBSERVATIONS OF SIGNIFICANTLY REDUCED CLEARANCE AND LIVER DEPOSITION PROPERTIES IN MICE

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Tanaka Kacunori , author

Bibliographic description in the original language

Tsutsui A. In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice / A. Tsutsui, A. Ogura, T. Tahara, S. Nozaki, S. Urano, M. Hara, S. Kojima, A. Kurbangalieva, H. Onoe, Y. Watanabe, N. Taniguchi, K. Tanaka // Org. Biomol. Chem. – 2016. – V. 14. – � 24. – P. 5755–5760.

Annotation

Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescent kinetic analysis was performed. In vivo imaging and fluorescence microscopic analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and its various associated disorders, which may serve as a platform for future research to better understand the processes and mechanisms of these disorders.

Keywords

advanced glycation end products, in vivo kinetics, molecular imaging

The name of the journal

Organic and Biomolecular Chemistry

URL

http://pubs.rsc.org/en/content/articlelanding/2016/ob/c6ob00098c#!divAbstract

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135634&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Tsutsui A. In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice / A. Tsutsui, A. Ogura, T. Tahara, S. Nozaki, S. Urano, M. Hara, S. Kojima, A. Kurbangalieva, H. Onoe, Y. Watanabe, N. Taniguchi, K. Tanaka // Org. Biomol. Chem. – 2016. – V. 14. – � 24. – P. 5755–5760.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135634&p_lang=2	ru_RU
dc.description.abstract	Organic and Biomolecular Chemistry	ru_RU
dc.description.abstract	Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and development of diabetes and uremia. To better understand these biological processes, investigation of the in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following the preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescent kinetic analysis was performed. In vivo imaging and fluorescence microscopic analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in the liver, i.e., Kupffer and other sinusoidal cells, but were unable to be properly cleared from the body. Overall, these results highlight an important link between AGEs and its various associated disorders, which may serve as a platform for future research to better understand the processes and mechanisms of these disorders.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	advanced glycation end products	ru_RU
dc.subject	in vivo kinetics	ru_RU
dc.subject	molecular imaging	ru_RU
dc.title	In vivo imaging of advanced glycation end products (AGEs) of albumin: first observations of significantly reduced clearance and liver deposition properties in mice	ru_RU
dc.type	Articles in international journals and collections	ru_RU