KFU. Card publication. Human adipose-derived stem cells stimulate neuroregeneration

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FEDERAL UNIVERSITY

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HUMAN ADIPOSE-DERIVED STEM CELLS STIMULATE NEUROREGENERATION

Form of presentation

Articles in international journals and collections

Year of publication

2016

Язык

английский

Authors, employees of KFU

Zhuravleva Margarita Nikolaevna, author

Kiyasov Andrey Pavlovich, author

Masgutov Ruslan Faridovich, author

Masgutova Galina Andreevna, author

Mukhamedshina Yana Olegovna, author

Mukhametshina Regina Rustamovna, author

Rizvanov Albert Anatolevich, author

Salafutdinov Ilnur Ildusovich, author

Other authors

Lima LM, Reis HJ, Palotás A Lima LM, Reis HJ, Palotás A , author

Bibliographic description in the original language

Masgutov RF Human adipose-derived stem cells stimulate neuroregeneration. Masgutov RF, Masgutova GA, Zhuravleva MN, Salafutdinov II, Mukhametshina RT, Mukhamedshina YO, Lima LM, Reis HJ, Kiyasov AP, Palotás A, Rizvanov AA.// Clin Exp Med. 2016 Aug;16(3):451-61. doi: 10.1007/s10238-015-0364-3. Epub 2015 Jun 6.

Annotation

Traumatic brain injuries and degenerative neurological disorders such as Alzheimer's dementia, Parkinson's disease, amyotrophic lateral sclerosis and many others are characterized by loss of brain cells and supporting structures. Restoring microanatomy and function using stem cells is a promising therapeutic approach. Among the many various sources, adipose-derived stem cells (ADSCs) are one of the most easily harvested alternatives, they multiply rapidly, and they demonstrate low immunogenicity with an ability to differentiate into several cell types. The objective of this study was to evaluate the effect of xenotransplanted human ADSCs on post-traumatic regeneration of rat sciatic nerve. Peripheral reconstruction following complete sciatic transection and autonerve grafting was complemented by intra-operative injection of hADSCs into the proximal and distal stumps. The injury caused gliosis and apoptosis of sensory neurons in the lumbar 5 (L5) ganglia in the control rodents; however,

Keywords

Autonerve graft; Human adipose-derived stem cell (hADSC); Peripheral nerve injury; Regenerative medicine; Repair; Xenotransplantation

The name of the journal

Clinical and Experimental Medicine

URL

http://link.springer.com/article/10.1007%2Fs10238-015-0364-3

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135676&p_lang=2

Resource files

File name	Size (MB)	Format
masgutov.pdf	1,84	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zhuravleva Margarita Nikolaevna	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Masgutov Ruslan Faridovich	ru_RU
dc.contributor.author	Masgutova Galina Andreevna	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Mukhametshina Regina Rustamovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Salafutdinov Ilnur Ildusovich	ru_RU
dc.contributor.author	Lima LM, Reis HJ, Palotás A Lima LM, Reis HJ, Palotás A	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Masgutov RF Human adipose-derived stem cells stimulate neuroregeneration. Masgutov RF, Masgutova GA, Zhuravleva MN, Salafutdinov II, Mukhametshina RT, Mukhamedshina YO, Lima LM, Reis HJ, Kiyasov AP, Palotás A, Rizvanov AA.// Clin Exp Med. 2016 Aug;16(3):451-61. doi: 10.1007/s10238-015-0364-3. Epub 2015 Jun 6.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135676&p_lang=2	ru_RU
dc.description.abstract	Clinical and Experimental Medicine	ru_RU
dc.description.abstract	Traumatic brain injuries and degenerative neurological disorders such as Alzheimer's dementia, Parkinson's disease, amyotrophic lateral sclerosis and many others are characterized by loss of brain cells and supporting structures. Restoring microanatomy and function using stem cells is a promising therapeutic approach. Among the many various sources, adipose-derived stem cells (ADSCs) are one of the most easily harvested alternatives, they multiply rapidly, and they demonstrate low immunogenicity with an ability to differentiate into several cell types. The objective of this study was to evaluate the effect of xenotransplanted human ADSCs on post-traumatic regeneration of rat sciatic nerve. Peripheral reconstruction following complete sciatic transection and autonerve grafting was complemented by intra-operative injection of hADSCs into the proximal and distal stumps. The injury caused gliosis and apoptosis of sensory neurons in the lumbar 5 (L5) ganglia in the control rodents; however,	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Human adipose-derived stem cells stimulate neuroregeneration	ru_RU
dc.type	Articles in international journals and collections	ru_RU