KFU. Card publication. Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase

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SCHWANN CELLS SENSE AND CONTROL ACETYLCHOLINE SPILLOVER AT THE NEUROMUSCULAR JUNCTION BY A7 NICOTINIC RECEPTORS AND BUTYRYLCHOLINESTERASE

Form of presentation

Articles in international journals and collections

Year of publication

2014

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Authors, employees of KFU

Nikolskiy Evgeniy Evgenevich, author

Nurullin Leniz Faritovich, author

Petrov Konstantin Aleksandrovich, author

Samigullin Dmitriy Vladimirovich, author

Bibliographic description in the original language

Petrov K.A. Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase / K.A. Petrov, E. Girard, A.D. Nikitashina, C. Colasante, V. Bernard, L. Nurullin, J. Leroy, D. Samigullin, O. Colak, E. Nikolsky, B. Plaud, E. Krejci //Journal of Neuroscience. - 2014. - Vol.34, Is.36. - P.11870-11883.

Annotation

Terminal Schwann cells (TSCs) are key components of the mammalian neuromuscular junction (NMJ). How the TSCs sense the synaptic activity in physiological conditions remains unclear. We have taken advantage of the distinct localization of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at the NMJ to bring out the function of different ACh receptors (AChRs). AChE is clustered by the collagen Q in the synaptic cleft and prevents the repetitive activation of muscle nicotinic AChRs. We found that BChE is anchored at the TSC. When BChE was specifically inhibited, ACh release was significant depressed through the activation of α7 nAChRs localized on the TSC and activated by the spillover of ACh. When both AChE and BChE were inhibited, the spillover increased and induced a dramatic reduction of ACh release that compromised the muscle twitch triggered by the nerve stimulation.

Keywords

acetylcholinesterase, glia, muscle, neuromuscular disease, synaptic homeostasis

The name of the journal

Journal of Neuroscience

URL

http://www.scopus.com/inward/record.url?eid=2-s2.0-84906901943&partnerID=40&md5=1a03b9a520c81afc117597f8a45221c4

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=135860&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Nikolskiy Evgeniy Evgenevich	ru_RU
dc.contributor.author	Nurullin Leniz Faritovich	ru_RU
dc.contributor.author	Petrov Konstantin Aleksandrovich	ru_RU
dc.contributor.author	Samigullin Dmitriy Vladimirovich	ru_RU
dc.date.accessioned	2014-01-01T00:00:00Z	ru_RU
dc.date.available	2014-01-01T00:00:00Z	ru_RU
dc.date.issued	2014	ru_RU
dc.identifier.citation	Petrov K.A. Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase / K.A. Petrov, E. Girard, A.D. Nikitashina, C. Colasante, V. Bernard, L. Nurullin, J. Leroy, D. Samigullin, O. Colak, E. Nikolsky, B. Plaud, E. Krejci //Journal of Neuroscience. - 2014. - Vol.34, Is.36. - P.11870-11883.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=135860&p_lang=2	ru_RU
dc.description.abstract	Journal of Neuroscience	ru_RU
dc.description.abstract	Terminal Schwann cells (TSCs) are key components of the mammalian neuromuscular junction (NMJ). How the TSCs sense the synaptic activity in physiological conditions remains unclear. We have taken advantage of the distinct localization of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) at the NMJ to bring out the function of different ACh receptors (AChRs). AChE is clustered by the collagen Q in the synaptic cleft and prevents the repetitive activation of muscle nicotinic AChRs. We found that BChE is anchored at the TSC. When BChE was specifically inhibited, ACh release was significant depressed through the activation of α7 nAChRs localized on the TSC and activated by the spillover of ACh. When both AChE and BChE were inhibited, the spillover increased and induced a dramatic reduction of ACh release that compromised the muscle twitch triggered by the nerve stimulation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	acetylcholinesterase	ru_RU
dc.subject	glia	ru_RU
dc.subject	muscle	ru_RU
dc.subject	neuromuscular disease	ru_RU
dc.subject	synaptic homeostasis	ru_RU
dc.title	Schwann cells sense and control acetylcholine spillover at the neuromuscular junction by a7 nicotinic receptors and butyrylcholinesterase	ru_RU
dc.type	Articles in international journals and collections	ru_RU