KFU. Card publication. Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice

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ACTION OF NMDA RECEPTORS AGONISTS ON AMPLITUDE OF MINIATURE ENDPLATE POTENTIALS IN PRIMA AND COLQ GENES KNOCKOUT MICE

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Nikolskiy Evgeniy Evgenevich, author

Petrov Konstantin Aleksandrovich, author

Bibliographic description in the original language

Proskurina S.E. Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice / S.E. Proskurina, K.A. Petrov, A.D. Kharlamova, E.Krejci, E.E. Nikolsky // Genes and Cells, Volume 10, Issue 4, 1 December 2015, Pages 60-62

Annotation

Previously it was shown that activation of NMDA receptors at neuromuscular junction can enhance nitric oxide (NO) production. NO, in turn, able to inhibit synaptic acetylcholinesterase activity and increases amplitude of synaptic responses. In this study we tested a hypothesis that molecular form of acetylcholinesterase anchored in plasma membrane could be more sensitive to endogenous NO inhibition than molecular form of acetylcholinesterase located on basal lamina. Experiments were performed on extensor digitorum longus of (-/-) PRiMA, (-/-) ColQ and wild type mice. After application of NMDA receptors agonists (glutamate and glycine) amplitude and decay time of miniature endplate potentials did not change in synapses of PRiMA or ColQ knock-out mice. Obtained results show that nitric oxide production owing to the activation of enzyme NO-synthase

Keywords

Acetylcholinesterase; Glutamate; Neuromuscular synapse; Nitric oxide; NMDA receptor

The name of the journal

Genes and Cells

URL

http://www.scopus.com/inward/record.url?eid=2-s2.0-84962217184&partnerID=40&md5=6fa36ad927f5c8bfa69e257557ecf429

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=136024&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Nikolskiy Evgeniy Evgenevich	ru_RU
dc.contributor.author	Petrov Konstantin Aleksandrovich	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Proskurina S.E. Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice / S.E. Proskurina, K.A. Petrov, A.D. Kharlamova, E.Krejci, E.E. Nikolsky // Genes and Cells, Volume 10, Issue 4, 1 December 2015, Pages 60-62	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=136024&p_lang=2	ru_RU
dc.description.abstract	Genes and Cells	ru_RU
dc.description.abstract	Previously it was shown that activation of NMDA receptors at neuromuscular junction can enhance nitric oxide (NO) production. NO, in turn, able to inhibit synaptic acetylcholinesterase activity and increases amplitude of synaptic responses. In this study we tested a hypothesis that molecular form of acetylcholinesterase anchored in plasma membrane could be more sensitive to endogenous NO inhibition than molecular form of acetylcholinesterase located on basal lamina. Experiments were performed on extensor digitorum longus of (-/-) PRiMA, (-/-) ColQ and wild type mice. After application of NMDA receptors agonists (glutamate and glycine) amplitude and decay time of miniature endplate potentials did not change in synapses of PRiMA or ColQ knock-out mice. Obtained results show that nitric oxide production owing to the activation of enzyme NO-synthase	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Action of NMDA receptors agonists on amplitude of miniature endplate potentials in PRiMa and ColQ genes knockout mice	ru_RU
dc.type	Articles in international journals and collections	ru_RU