KFU. Card publication. Role of autoantibody in the pathogenesis of patients with atopic bronchial asthma

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

ROLE OF AUTOANTIBODY IN THE PATHOGENESIS OF PATIENTS WITH ATOPIC BRONCHIAL ASTHMA

Form of presentation

Articles in international journals and collections

Year of publication

2015

��

��

Authors, employees of KFU

Abramova Zinaida Ivanovna, author

Skibo Yuliya Valerevna, author

Bibliographic description in the original language

Vodounon C.A. Role of autoantibody in the pathogenesis of patients with atopic bronchial asthma/Vodounon C. A., Abramova Z. I., Chab, C. B., Kurbanov R. A., Reshetnikova D. I., Skibo Y. V. ... Baba-Moussa, L//Research Journal of Immunology. - 2015. - Vol.8, Is.1. - P.1-16. (SJR 0.1008, RG Journal Impact: 3.55 *)

Annotation

Abstract: Bronchial Asthma is considered as the most spreading human chronic diseases. The diagnostic of the disease at its beginning is very difficult because the light forms of the disease can't be diagnosed as the symptoms are not very well developed at the outbreak of the disease. The objective of this study was to correlate the climatic and geographic factors and the environmental conditions in the occurrence of Atopic Bronchial Asthma and other autoimmune phenomena, for example the prevalence of abzymes in the pathogenesis of Atopic Bronchial Asthma. In the present work, enzyme linked to immune sorbent assay method and the methods of electrophoresis in agarose gel were used. The results of our study showed the discovery of an excessive auto-antibodies to DNA in the blood vessels of patients with atopic bronchial asthma and there was a direct correlation dependence (r = 0.0005) between the level of auto-antibodies to DNA and the severity of the Atopic Bronchial Asthma. The detected auto-antibodies possess catalytic activity of DNA, enzymatic specificity which is associated with the degree of severity of disease. The auto antibodies in patients suffering from severe forms of Bronchial Asthma are specific for monofilament DNA and antibodies in the blood serum of the patients with the light form of asthma is heterogenic: besides antibodies with monofilament substratum, some specific antibodies with bi-filament DNA circulate. Therefore, in the serum of the patients suffering from Atopic Bronchial Asthma antibodies with Catalytic activity DNA was observed-that is abzymes. It was suggested that these “abzymes” may be directly involved in the removal of debris produced by the metabolism of organism under physiological conditions. Considering all these facts, Abzymes can be regarded as serological markers of autoimmunity and needs to be tested while investigating autoimmunity especially in Atopic Bronchial Asthma and it may also serve as an additional criterion for the diagnosis of asthma even in the early stages and can also help in the evaluation of the effectiveness of the treatment.

Keywords

Autoantibody, pathogenesis, atopic bronchial asthma

The name of the journal

Research Journal of Immunology

URL

https://scialert.net/fulltext/?doi=rji.2015.1.16&org=11

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=136767&p_lang=2

Resource files

File name	Size (MB)	Format
Role_of_autoantibody_in_the_pathogenesis_of_patients_with_asthma.pdf	0,88	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abramova Zinaida Ivanovna	ru_RU
dc.contributor.author	Skibo Yuliya Valerevna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Vodounon C.A. Role of autoantibody in the pathogenesis of patients with atopic bronchial asthma/Vodounon C. A., Abramova Z. I., Chab, C. B., Kurbanov R. A., Reshetnikova D. I., Skibo Y. V. ... Baba-Moussa, L//Research Journal of Immunology. - 2015. - Vol.8, Is.1. - P.1-16. (SJR 0.1008, RG Journal Impact: 3.55 *)	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=136767&p_lang=2	ru_RU
dc.description.abstract	Research Journal of Immunology	ru_RU
dc.description.abstract	Abstract: Bronchial Asthma is considered as the most spreading human chronic diseases. The diagnostic of the disease at its beginning is very difficult because the light forms of the disease can't be diagnosed as the symptoms are not very well developed at the outbreak of the disease. The objective of this study was to correlate the climatic and geographic factors and the environmental conditions in the occurrence of Atopic Bronchial Asthma and other autoimmune phenomena, for example the prevalence of abzymes in the pathogenesis of Atopic Bronchial Asthma. In the present work, enzyme linked to immune sorbent assay method and the methods of electrophoresis in agarose gel were used. The results of our study showed the discovery of an excessive auto-antibodies to DNA in the blood vessels of patients with atopic bronchial asthma and there was a direct correlation dependence (r = 0.0005) between the level of auto-antibodies to DNA and the severity of the Atopic Bronchial Asthma. The detected auto-antibodies possess catalytic activity of DNA, enzymatic specificity which is associated with the degree of severity of disease. The auto antibodies in patients suffering from severe forms of Bronchial Asthma are specific for monofilament DNA and antibodies in the blood serum of the patients with the light form of asthma is heterogenic: besides antibodies with monofilament substratum, some specific antibodies with bi-filament DNA circulate. Therefore, in the serum of the patients suffering from Atopic Bronchial Asthma antibodies with Catalytic activity DNA was observed-that is abzymes. It was suggested that these “abzymes” may be directly involved in the removal of debris produced by the metabolism of organism under physiological conditions. Considering all these facts, Abzymes can be regarded as serological markers of autoimmunity and needs to be tested while investigating autoimmunity especially in Atopic Bronchial Asthma and it may also serve as an additional criterion for the diagnosis of asthma even in the early stages and can also help in the evaluation of the effectiveness of the treatment.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Autoantibody	ru_RU
dc.subject	pathogenesis	ru_RU
dc.subject	atopic bronchial asthma	ru_RU
dc.title	Role of autoantibody in the pathogenesis of patients with atopic bronchial asthma	ru_RU
dc.type	Articles in international journals and collections	ru_RU