KFU. Card publication. Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia

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FEDERAL UNIVERSITY

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CHANGES OF NITRIC OXIDE CONTENT IN THE RAT HIPPOCAMPUS, HEART AND LIVER IN ACUTE PHASE OF ISCHEMIA

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Andrianov Vyacheslav Vadimovich, author

Bogodvid Tatyana Khalilovna, author

Gaynutdinov Khalil Latypovich, author

Other authors

Denisov Andrey Anatolevich, author

Dosina Margarita Olegovna, author

Iyudin Vasiliy Sergeevich, author

Kulchickiy Vladimir Adamovich, author

Pashkevich Svetlana Georgievna, author

Bibliographic description in the original language

Andrianov V.V. Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia / V. V. Andrianov, S. G. Pashkevich, G. G. Yafarova, A. A. Denisov, V. S. Iyudin, T. Kh. Bogodvid, M. O. Dosina, V. A. Kulchitsky, Kh. L. Gainutdinov // Appl. Magn. Reson. - 2016. - V. 47. - N 9. - P. 965-976.

Annotation

Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showed that after the emergence of signs of ischemic stroke, 5 hours after the start of ischemia, the content of NO in the hippocampus decreased 2-3 fold and this decrease was maintained at 24 and 72 hours. Deserving special attention is the data demonstrating that there is a greater decrease of NO production in the tissues of the heart and liver than in the brain. Consequently, the change in intensity of NO production in the modeling of ischemic events in the brain has a systemic, not a local character.

Keywords

nitric oxide, electron paramagnetic resonance, spin trap, ischemic brain stroke

The name of the journal

APPLIED MAGNETIC RESONANCE

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=138581&p_lang=2

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Andrianov Vyacheslav Vadimovich	ru_RU
dc.contributor.author	Bogodvid Tatyana Khalilovna	ru_RU
dc.contributor.author	Gaynutdinov Khalil Latypovich	ru_RU
dc.contributor.author	Denisov Andrey Anatolevich	ru_RU
dc.contributor.author	Dosina Margarita Olegovna	ru_RU
dc.contributor.author	Iyudin Vasiliy Sergeevich	ru_RU
dc.contributor.author	Kulchickiy Vladimir Adamovich	ru_RU
dc.contributor.author	Pashkevich Svetlana Georgievna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Andrianov V.V. Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia / V. V. Andrianov, S. G. Pashkevich, G. G. Yafarova, A. A. Denisov, V. S. Iyudin, T. Kh. Bogodvid, M. O. Dosina, V. A. Kulchitsky, Kh. L. Gainutdinov // Appl. Magn. Reson. - 2016. - V. 47. - N 9. - P. 965-976.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=138581&p_lang=2	ru_RU
dc.description.abstract	APPLIED MAGNETIC RESONANCE	ru_RU
dc.description.abstract	Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showed that after the emergence of signs of ischemic stroke, 5 hours after the start of ischemia, the content of NO in the hippocampus decreased 2-3 fold and this decrease was maintained at 24 and 72 hours. Deserving special attention is the data demonstrating that there is a greater decrease of NO production in the tissues of the heart and liver than in the brain. Consequently, the change in intensity of NO production in the modeling of ischemic events in the brain has a systemic, not a local character.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	nitric oxide	ru_RU
dc.subject	electron paramagnetic resonance	ru_RU
dc.subject	spin trap	ru_RU
dc.subject	ischemic brain stroke	ru_RU
dc.title	Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia	ru_RU
dc.type	Articles in international journals and collections	ru_RU