KFU. Card publication. Role of purinoceptors and npy-receptors in the regulation of rat heart in postnatal ontogenesis

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ROLE OF PURINOCEPTORS AND NPY-RECEPTORS IN THE REGULATION OF RAT HEART IN POSTNATAL ONTOGENESIS

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Zverev Aleksey Anatolevich, author

Zefirov Timur Lvovich, author

Krylova Alevtina Vasilevna, author

Bibliographic description in the original language

Zverev, A.A. Role of purinoceptors and npy-receptors in the regulation of rat heart in postnatal ontogenesis / A.A. Zverev , T.A. Anikina, A. V. Krulova, T.L. Zefirov // International Journal of Pharmacy and Technology, - 2016, - � 8, Issue 2, P. 14592-14598

Annotation

ATP and neuropeptide Y are present in central and peripheral nervous systems. Being in neurons in conjunction with noradrenaline and acetylcholine they act on own receptors, strengthening or weakening major mediator effects. ATP, neuropeptide Y and their analogues were studied on the myocardial contractility of atria and ventricles of rats during an early postnatal ontogenesis. ATP and its persistent analogues increase the strength of myocardial contractions, acting through its own P2 receptors. The positive inotropic effect confirms their participation in the myocardium contraction among growing animals by the addition of NPY receptor agonists. During the early stages of postnatal ontogenesis, in terms of sympathetic and parasympathetic regulatory effects on heart immaturity, its receptor system, different mechanisms of cotransmitter influence pn the effects of the major mediators are possible. ? 2016, International Journal of Pharmacy and Technology. All rights reserved.

Keywords

ATP; Contractility; Neuropeptide Y; Ontogenesis; Rat

The name of the journal

International Journal of Pharmacy and Technology

URL

https://www.scopus.com/record/display.uri?eid=2-s2.0-84978468655&origin=resultslist&sort=plf-f&src=s&st1=Zverev+A.A.&st2=&sid=0FE3F95B2FBC05A7707466DAACE307BB.wsnAw8kcdt7IPYLO0V48gA%3a70&sot=b&sdt=b&sl=24&s=AUTHOR-NAME%28Zverev+A.A.%29&relpos=6&citeCnt=0&searchTerm=

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=140263&p_lang=2

Resource files

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Full metadata record

Field DC	Value	Language
dc.contributor.author	Zverev Aleksey Anatolevich	ru_RU
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Krylova Alevtina Vasilevna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Zverev, A.A. Role of purinoceptors and npy-receptors in the regulation of rat heart in postnatal ontogenesis / A.A. Zverev , T.A. Anikina, A. V. Krulova, T.L. Zefirov // International Journal of Pharmacy and Technology, - 2016, - � 8, Issue 2, P. 14592-14598	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=140263&p_lang=2	ru_RU
dc.description.abstract	International Journal of Pharmacy and Technology	ru_RU
dc.description.abstract	ATP and neuropeptide Y are present in central and peripheral nervous systems. Being in neurons in conjunction with noradrenaline and acetylcholine they act on own receptors, strengthening or weakening major mediator effects. ATP, neuropeptide Y and their analogues were studied on the myocardial contractility of atria and ventricles of rats during an early postnatal ontogenesis. ATP and its persistent analogues increase the strength of myocardial contractions, acting through its own P2 receptors. The positive inotropic effect confirms their participation in the myocardium contraction among growing animals by the addition of NPY receptor agonists. During the early stages of postnatal ontogenesis, in terms of sympathetic and parasympathetic regulatory effects on heart immaturity, its receptor system, different mechanisms of cotransmitter influence pn the effects of the major mediators are possible. ? 2016, International Journal of Pharmacy and Technology. All rights reserved.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Role of purinoceptors and npy-receptors in the regulation of rat heart in postnatal ontogenesis	ru_RU
dc.type	Articles in international journals and collections	ru_RU