KFU. Card publication. Sequential double “clicks” toward structurally well-defined heterogeneous N-glycoclusters: the importance of cluster heterogeneity on pattern recognition in vivo

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SEQUENTIAL DOUBLE &LDQUO;CLICKS&RDQUO; TOWARD STRUCTURALLY WELL-DEFINED HETEROGENEOUS N-GLYCOCLUSTERS: THE IMPORTANCE OF CLUSTER HETEROGENEITY ON PATTERN RECOGNITION IN VIVO

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Latypova Liliya Zinnurovna, author

Bibliographic description in the original language

Latypova, L. Sequential double “clicks” toward structurally well-defined heterogeneous N-glycoclusters: the importance of cluster heterogeneity on pattern recognition in vivo / L. Latypova, R. Sibgatullina, A. Ogura, K. Fujiki, A. Khabibrakhmanova, T. Tahara, S. Nozaki, S. Urano, K. Tsubokura, H. Onoe, Y. Watanabe, A. Kurbangalieva, K. Tanaka. // Advanced Science – 2017. – V. 4. – � 2. doi: 10.1002/advs.201600394

Annotation

Two structurally distinct N-glycans were initially united in a single azide-terminated compound that was then immobilized onto albumin via a double click procedure. Noninvasive imaging data revealed that the excretion pathway of the structurally well-defined heterogeneous glycoclusters was not simply a combination of the excretion pathways taken by the homogeneous or arbitrarily arranged heterogeneous glycoclusters. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, played an important role in the in vivo kinetics and organ-selective accumulation through glycan pattern recognition mechanisms.

Keywords

N-glycoalbumin, heterogeneity, pattern recognition, in vivo kinetics, biodistribution, noninvasive fluorescence imaging

The name of the journal

Advanced Science

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=151881&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Latypova Liliya Zinnurovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Latypova, L. Sequential double “clicks” toward structurally well-defined heterogeneous N-glycoclusters: the importance of cluster heterogeneity on pattern recognition in vivo / L. Latypova, R. Sibgatullina, A. Ogura, K. Fujiki, A. Khabibrakhmanova, T. Tahara, S. Nozaki, S. Urano, K. Tsubokura, H. Onoe, Y. Watanabe, A. Kurbangalieva, K. Tanaka. // Advanced Science – 2017. – V. 4. – � 2. doi: 10.1002/advs.201600394	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=151881&p_lang=2	ru_RU
dc.description.abstract	Advanced Science	ru_RU
dc.description.abstract	Two structurally distinct N-glycans were initially united in a single azide-terminated compound that was then immobilized onto albumin via a double click procedure. Noninvasive imaging data revealed that the excretion pathway of the structurally well-defined heterogeneous glycoclusters was not simply a combination of the excretion pathways taken by the homogeneous or arbitrarily arranged heterogeneous glycoclusters. The number of glycan molecules present, in addition to the spatial arrangement of glycans in the heterogeneous glycoclusters, played an important role in the in vivo kinetics and organ-selective accumulation through glycan pattern recognition mechanisms.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	N-glycoalbumin	ru_RU
dc.subject	heterogeneity	ru_RU
dc.subject	pattern recognition	ru_RU
dc.subject	in vivo kinetics	ru_RU
dc.subject	biodistribution	ru_RU
dc.subject	noninvasive fluorescence imaging	ru_RU
dc.title	Sequential double “clicks” toward structurally well-defined heterogeneous N-glycoclusters: the importance of cluster heterogeneity on pattern recognition in vivo	ru_RU
dc.type	Articles in international journals and collections	ru_RU