Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
INHIBITION OF CORTICAL ACTIVITY AND APOPTOSIS CAUSED BY ETHANOL IN NEONATAL RATS IN VIVO
Form of presentationArticles in international journals and collections
Year of publication2017
Языкрусский
  • Sitdikova Guzel Faritovna, author
  • Bibliographic description in the original language Julia Lebedeva1,2,3,?, Andrei Zakharov1,4,?, Elena Ogievetsky2,3, Alina Minlebaeva2,3, Rustem Kurbanov1, Elena Gerasimova1, Guzel Sitdikova1,? and Roustem Khazipov1 Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo // Cerebral Cortex, February 2017;27: 1068–1082
    Annotation Alcohol consumption during pregnancy causes fetal alcohol spectrum disorder, which includes neuroapoptosis and neurobehavioral deficits. The neuroapoptotic effects of alcohol have been hypothesized to involve suppression of brain activity. However, in vitro studies suggest that ethanol acts as a potent stimulant of cortical activity.We explored the effects of alcohol (1–6 g/kg) on electrical activity in the rat somatosensory cortex in vivo at postnatal days P1–23 and compared them with its apoptotic actions. At P4–7, when the peak of alcohol-induced apoptosiswas observed, alcohol strongly suppressed spontaneous gamma and spindle-bursts and almost completely silenced neurons in a dose-dependent manner. The dose-dependence of suppression of neuronal activity strongly correlated with the alcohol-induced neuroapoptosis. Alcohol also profoundly inhibited sensory-evoked bursts and suppressed motor activity, a physiological trigger of cortical activity bursts in newborns. The suppressive effe
    Keywords apoptosis, electroencephalogram, ethanol, fetal alcohol syndrome, neonate, neuronal network, rat, sensory-evoked potentials
    The name of the journal Cerebral Cortex
    URL https://academic.oup.com/cercor/article/27/2/1068/3056288/Inhibition-of-Cortical-Activity-and-Apoptosis
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=154353&p_lang=2

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