KFU. Card publication. Effects of Haloperidol on Acute Carrageenan-Induced Inflammation

KAZAN
FEDERAL UNIVERSITY

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EFFECTS OF HALOPERIDOL ON ACUTE CARRAGEENAN-INDUCED INFLAMMATION

Form of presentation

Articles in international journals and collections

Year of publication

2017

Язык

английский

Authors, employees of KFU

Ziganshina Liliya Evgenevna, author

Kong Khong Khan , author

Khaziakhmetova Veronika Nikolaevna, author

Bibliographic description in the original language

Khaziakhmetova V.The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation/Khaziakhmetova, V., Baiysbekov K., Torobekov Sh., Hanh Cong, Ziganshina L. // NanoBioScience. - 2017 – pp 442–445 DOI: 10.1007/s12668-017-0392-4.

Annotation

The objective of the study was to assess potential anti-inflammatory or pro-inflammatory effects of haloperidol, a classic typical neuroleptic, a butyrophenone derivative. It has been hypothesized that the anti-inflammatory mechanisms of some psychotropic drugs might become a rationale for their use for potential prevention of neurodegenirative diseases, including Alzheimer's, which are known to include chronic inflammation as disease progression component. We looked at the effects of haloperidol on the acute carrageenan-induced inflammation of rat paws and showed that haloperidol with prolonged use (for 7 days prior to edema modeling) considerably increased the inflammatory response at 48 h. A single dose of haloperidol also stimulated the progression of inflammation but at earlier time points—at 3 and 4 h after carrageenan injection.

Keywords

Acute inflammation, Carrageenan, Haloperidol,Rats

The name of the journal

Springerlink

URL

http://link.springer.com/article/10.1007/s12668-017-0392-4

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=154411&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Liliya Evgenevna	ru_RU
dc.contributor.author	Kong Khong Khan	ru_RU
dc.contributor.author	Khaziakhmetova Veronika Nikolaevna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Khaziakhmetova V.The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation/Khaziakhmetova, V., Baiysbekov K., Torobekov Sh., Hanh Cong, Ziganshina L. // NanoBioScience. - 2017 – pp 442–445 DOI: 10.1007/s12668-017-0392-4.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=154411&p_lang=2	ru_RU
dc.description.abstract	Springerlink	ru_RU
dc.description.abstract	The objective of the study was to assess potential anti-inflammatory or pro-inflammatory effects of haloperidol, a classic typical neuroleptic, a butyrophenone derivative. It has been hypothesized that the anti-inflammatory mechanisms of some psychotropic drugs might become a rationale for their use for potential prevention of neurodegenirative diseases, including Alzheimer's, which are known to include chronic inflammation as disease progression component. We looked at the effects of haloperidol on the acute carrageenan-induced inflammation of rat paws and showed that haloperidol with prolonged use (for 7 days prior to edema modeling) considerably increased the inflammatory response at 48 h. A single dose of haloperidol also stimulated the progression of inflammation but at earlier time points—at 3 and 4 h after carrageenan injection.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acute inflammation	ru_RU
dc.subject	Carrageenan	ru_RU
dc.subject	Haloperidol	ru_RU
dc.subject	Rats	ru_RU
dc.title	Effects of Haloperidol on Acute Carrageenan-Induced Inflammation	ru_RU
dc.type	Articles in international journals and collections	ru_RU