KFU. Card publication. Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus

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POSTSYNAPTIC GABA(B) RECEPTORS CONTRIBUTE TO THE TERMINATION OF GIANT DEPOLARIZING POTENTIALS IN CA3 NEONATAL RAT HIPPOCAMPUS

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Minlebaev Marat Gusmanovich, author

Mukhtarov Marat Rakhimzyanovich, author

Khazipov Rustem Narimanovich, author

Khalilov Ilgam Adegamovich, author

Authors, postgraduates KFU

Yuzekaeva Elvira Razilevna, postgraduate kfu

Bibliographic description in the original language

Khalilov I.Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus / I. Khalilov, M. Minlebaev, M. Mukhtarov, E. Juzekaeva, R. Khazipov // Front Cell Neurosci. ? 2017.

Annotation

During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and ﬁring of CA3 pyramidal cells followed by afterhyperpolarization (GDP-AHP). Here, we explored the properties of GDP-AHP in CA3 pyramidal cells using gramicidin perforated patch clamp recordings from neonatal rat hippocampal slices. We found that GDP-AHP occurs independently of whether CA3 pyramidal cells ﬁre action potentials (APs) or remain silent during GDPs. However, the amplitude of GDP-AHP increased with the number of APs the cells ﬁred during GDPs. The reversal potential of the GDP-AHP was close to the potassium equilibrium potential.

Keywords

GABA, giant depolarizing potentials, neonatal, hippocampus, patch-clamp techniques, development

The name of the journal

Frontiers in Cellular Neuroscience

URL

https://www.frontiersin.org/articles/10.3389/fncel.2017.00179/full

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=173304&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Minlebaev Marat Gusmanovich	ru_RU
dc.contributor.author	Mukhtarov Marat Rakhimzyanovich	ru_RU
dc.contributor.author	Khazipov Rustem Narimanovich	ru_RU
dc.contributor.author	Khalilov Ilgam Adegamovich	ru_RU
dc.contributor.author	Yuzekaeva Elvira Razilevna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Khalilov I.Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus / I. Khalilov, M. Minlebaev, M. Mukhtarov, E. Juzekaeva, R. Khazipov // Front Cell Neurosci. ? 2017.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=173304&p_lang=2	ru_RU
dc.description.abstract	Frontiers in Cellular Neuroscience	ru_RU
dc.description.abstract	During development, hippocampal CA3 network generates recurrent population bursts, so-called Giant Depolarizing Potentials (GDPs). GDPs are characterized by synchronous depolarization and ﬁring of CA3 pyramidal cells followed by afterhyperpolarization (GDP-AHP). Here, we explored the properties of GDP-AHP in CA3 pyramidal cells using gramicidin perforated patch clamp recordings from neonatal rat hippocampal slices. We found that GDP-AHP occurs independently of whether CA3 pyramidal cells ﬁre action potentials (APs) or remain silent during GDPs. However, the amplitude of GDP-AHP increased with the number of APs the cells ﬁred during GDPs. The reversal potential of the GDP-AHP was close to the potassium equilibrium potential.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	GABA	ru_RU
dc.subject	giant depolarizing potentials	ru_RU
dc.subject	neonatal	ru_RU
dc.subject	hippocampus	ru_RU
dc.subject	patch-clamp techniques	ru_RU
dc.subject	development	ru_RU
dc.title	Postsynaptic GABA(B) Receptors Contribute to the Termination of Giant Depolarizing Potentials in CA3 Neonatal Rat Hippocampus	ru_RU
dc.type	Articles in international journals and collections	ru_RU