KFU. Card publication. Modeling the Co2+ Binding to Amyloid Peptide Aβ13?23 in Water Environment by NMR Spectroscopy

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

MODELING THE CO2+ BINDING TO AMYLOID PEPTIDE Aβ13?23 IN WATER ENVIRONMENT BY NMR SPECTROSCOPY

Form of presentation

Articles in international journals and collections

Year of publication

2017

Authors, employees of KFU

Blokhin Dmitriy Sergeevich, author

Klochkov Vladimir Vasilevich, author

Authors, postgraduates KFU

Abdrakhmanov Rustam Zhamilevich, postgraduate kfu

Bibliographic description in the original language

Alzheimer's disease is a fatal neurodegenerative disorder involving the abnormal accumulation and deposition of peptides (amyloid-β, Aβ) derived from the amyloid precursor protein. Various factors that cause pathology data are revealed, but, at the moment, there is no clear understanding of the processes of plaque formation. This is interesting and actual problem because metals such as zinc, manganese, and others induce Aβ aggregation and fibril formation at high metal concentrations, while low concentration metal ions selectively destabilize the Aβ oligomeric species. In present paper, we report a structural studies of the Co2+ ion binding sites of Aβ fragments in water environment by 1D (1H) and 2D (1H-1H) NMR spectroscopy. According to the observed changes in the NMR spectra that were determined, the cobalt binding center of the Aβ13?23 peptide is associated with the aspartate and glutamine residues. Structural model of cobalt associated with Aβ peptide was obtained.

Keywords

Amyloid peptideAβ13-23, NMR, model peptide, neurodegeneration, structure, alzheimer?s disease.

The name of the journal

BioNanoScience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=182742&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Blokhin Dmitriy Sergeevich	ru_RU
dc.contributor.author	Klochkov Vladimir Vasilevich	ru_RU
dc.contributor.author	Abdrakhmanov Rustam Zhamilevich	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Alzheimer's disease is a fatal neurodegenerative disorder involving the abnormal accumulation and deposition of peptides (amyloid-β, Aβ) derived from the amyloid precursor protein. Various factors that cause pathology data are revealed, but, at the moment, there is no clear understanding of the processes of plaque formation. This is interesting and actual problem because metals such as zinc, manganese, and others induce Aβ aggregation and fibril formation at high metal concentrations, while low concentration metal ions selectively destabilize the Aβ oligomeric species. In present paper, we report a structural studies of the Co2+ ion binding sites of Aβ fragments in water environment by 1D (1H) and 2D (1H-1H) NMR spectroscopy. According to the observed changes in the NMR spectra that were determined, the cobalt binding center of the Aβ13?23 peptide is associated with the aspartate and glutamine residues. Structural model of cobalt associated with Aβ peptide was obtained.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=182742&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Amyloid peptideAβ13-23	ru_RU
dc.subject	NMR	ru_RU
dc.subject	model peptide	ru_RU
dc.subject	neurodegeneration	ru_RU
dc.subject	structure	ru_RU
dc.subject	alzheimer?s disease.	ru_RU
dc.title	Modeling the Co2+ Binding to Amyloid Peptide Aβ13?23 in Water Environment by NMR Spectroscopy	ru_RU
dc.type	Articles in international journals and collections	ru_RU