KFU. Card publication. Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats.

- RUS
- 中文
- ES

ADIPOSE-DERIVED MESENCHYMAL STEM CELL APPLICATION COMBINED WITH FIBRIN MATRIX PROMOTES STRUCTURAL AND FUNCTIONAL RECOVERY FOLLOWING SPINAL CORD INJURY IN RATS.

Form of presentation

Articles in international journals and collections

Year of publication

2018

Authors, employees of KFU

Akhmetzyanova Elvira Ruslanovna, author

Galieva Luiza Ramilevna, author

Garanina Ekaterina Evgenevna, author

Zakirova Elena Yurevna, author

Kiyasov Andrey Pavlovich, author

Kostennikov Aleksandr Aleksandrovich, author

Mukhamedshina Yana Olegovna, author

Rizvanov Albert Anatolevich, author

Rogozhin Aleksandr Aleksandrovich, author

Authors, postgraduates KFU

Akhmetzyanova Elvira Ruslanovna, postgraduate kfu

Bibliographic description in the original language

Mukhamedshina, Y.O., Akhmetzyanova, E.R., Kostennikov, A.A., Zakirova, E.Y., Galieva, L.R., Garanina, E.E., Rogozin, A.A., Kiassov, A.P. and Rizvanov, A.A., 2018. Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats. Frontiers in pharmacology, 9, p.343.

Annotation

The use of stem and progenitor cells to restore damaged organs and tissues, in particular, the central nervous system, is currently considered a most promising therapy in regenerative medicine. At the same time, another approach aimed at stimulating regeneration with the use of stem cells encapsulated into a biopolymer matrix and capable of creating a specific microenvironment for the implanted cells similar to the natural extracellular matrix is under active development. Here, we study effects of the application of adipose-derived mesenchymal stem cells (AD-MSCs) combined with a fibrin matrix on post-traumatic reactions in the spinal cord in rats. The AD-MSC application is found to exert a positive impact on the functional and structural recovery after spinal cord injury (SCI) that has been confirmed by the results of behavioral/electrophysiological and morphometric studies demonstrating reduced area of abnormal cavities and enhanced tissue retention in the site of injury.

Keywords

spinal cord injury, mesenchymal stem cells, adipose tissue, fibrin matrix, rats

The name of the journal

FRONTIERS IN PHARMACOLOGY

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=186322&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.contributor.author	Galieva Luiza Ramilevna	ru_RU
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Zakirova Elena Yurevna	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Kostennikov Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Rogozhin Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Mukhamedshina, Y.O., Akhmetzyanova, E.R., Kostennikov, A.A., Zakirova, E.Y., Galieva, L.R., Garanina, E.E., Rogozin, A.A., Kiassov, A.P. and Rizvanov, A.A., 2018. Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats. Frontiers in pharmacology, 9, p.343.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=186322&p_lang=2	ru_RU
dc.description.abstract	FRONTIERS IN PHARMACOLOGY	ru_RU
dc.description.abstract	The use of stem and progenitor cells to restore damaged organs and tissues, in particular, the central nervous system, is currently considered a most promising therapy in regenerative medicine. At the same time, another approach aimed at stimulating regeneration with the use of stem cells encapsulated into a biopolymer matrix and capable of creating a specific microenvironment for the implanted cells similar to the natural extracellular matrix is under active development. Here, we study effects of the application of adipose-derived mesenchymal stem cells (AD-MSCs) combined with a fibrin matrix on post-traumatic reactions in the spinal cord in rats. The AD-MSC application is found to exert a positive impact on the functional and structural recovery after spinal cord injury (SCI) that has been confirmed by the results of behavioral/electrophysiological and morphometric studies demonstrating reduced area of abnormal cavities and enhanced tissue retention in the site of injury.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	mesenchymal stem cells	ru_RU
dc.subject	adipose tissue	ru_RU
dc.subject	fibrin matrix	ru_RU
dc.subject	rats	ru_RU
dc.title	Adipose-Derived Mesenchymal Stem Cell Application Combined With Fibrin Matrix Promotes Structural and Functional Recovery Following Spinal Cord Injury in Rats.	ru_RU
dc.type	Articles in international journals and collections	ru_RU