KFU. Card publication. The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats.

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FEDERAL UNIVERSITY

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THE INFLUENCE OF IF-CURRENT BLOCKADE ON THE PARAMETERS OF ACTION POTENTIAL AMONG 1-WEEK AND 20-WEEK-OLD RATS.

Form of presentation

Articles in Russian journals and collections

Year of publication

2018

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Faskhutdinov Lenar Ilsurovich, author

Bibliographic description in the original language

Faskhutdinov L.I. The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats. / L.I. Faskhutdinov, N.I. Ziyatdinova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences November–December 2018 RJPBCS 9(6) Page No. 472-478.

Annotation

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES

Keywords

action potential, action potential duration, the duration at repolarization level of 50%, the duration at repolarization level of 90%,heart, rat

The name of the journal

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES

URL

https://www.rjpbcs.com/2018_9.6.html

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=188559&p_lang=2

Resource files

File name	Size (MB)	Format
F__58_.pdf	0,30	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Faskhutdinov Lenar Ilsurovich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Faskhutdinov L.I. The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats. / L.I. Faskhutdinov, N.I. Ziyatdinova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences November–December 2018 RJPBCS 9(6) Page No. 472-478.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=188559&p_lang=2	ru_RU
dc.description.abstract	RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES	ru_RU
dc.description.abstract	RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES	ru_RU
dc.description.abstract	This type of currents participates in slow diastolic depolarization and is considered the sinus-atrial node current. In literary sources, much is said about the fact that If-currents are present in atypical cardiomyocytes. But the information about the role of currents in functional cardiomyocytes during the generation of action potential is scarce. One of the common current blockers activated by hyperpolarization is ZD7288. The results of experiments showed that ZD7288 in concentrations of 10-9 M and 10-8 M did not cause significant changes in action potential parameters. The remaining concentrations cause a significant increase of the action potential duration at the repolarization level of 50%, 90%, and 100%. Consequently, the blockade of currents activated by hyperpolarization causes the increase of the action potential time parameters.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	action potential	ru_RU
dc.subject	action potential duration	ru_RU
dc.subject	the duration at repolarization level of 50%	ru_RU
dc.subject	the duration at repolarization level of 90%	ru_RU
dc.subject	heart	ru_RU
dc.subject	rat	ru_RU
dc.title	The Influence Of If-Current Blockade On The Parameters Of Action Potential Among 1-Week And 20-Week-Old Rats.	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU